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Yale Residency - Rabbits, Guinea Pigs, Misc. Rodents > 11. The Guinea Pig and Hamster in Research > Flashcards

11. The Guinea Pig and Hamster in Research Flashcards

1
Q

Guinea pigs are in what suborder?

A

Histricomorphs (Porcupine like) - masseter passes through large infraorbital foramen

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2
Q

Guinea pigs are old or new world rodents?

A

New world

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3
Q

Guinea pigs were the first to b emaintained in axenic state. what does this mean?

A

Free of other microorganisms

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4
Q

Describe length and texture of coats in English, Peruvian, Abyssinian GPs

A

English: Short and straight
Peruvian: Long (whorled or straight)
Abyssinian: Short, rough hair in whorls

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5
Q

Outbred stock of GP

A

Dunkin-Hartley

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6
Q

Inbred strain of GP

A

Strain 2, Strain 13, JY1, JY2, Weiser-Maple

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7
Q

JY1 and JY2 GPs

A

Used for superovulation, embryo transfer, embryo culture

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8
Q

Weiser-Maple strain

A

Radical and vertical growth patterns of melanocytes

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9
Q

Strain 2 and Strain 13

A

multicolored, lower growth rates, less robust

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10
Q

Hartley A

A

Natural resistance to T. pallidum

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11
Q

Complement 4 deficient

A

100% susceptible to T. pallidum - partial autosomal dominant

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12
Q

Waltzing GPs

A

Deafness and circling behavior - Autosomal dominant

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13
Q

German waltzing

A

Inner ear deficiency - deafness, ataxia, circling - recessive
Homozygotes affected, hets have increased resistance to noise induced trauma

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14
Q

Hairless athymic

A

immunodeficient (agammaglobulinemia)

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15
Q

Hairless euthymic

A

Immunocompetent

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16
Q

Life span of GPs

A

2-8yrs

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17
Q

Sexual maturity of GPs

A

60-90days

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18
Q

Estrus cycle length GP

A

16-18 days

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19
Q

Gestation length GP

A

60-65 days

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20
Q

Avg litter size GP

A

2-4

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21
Q

GPs are unable to synthesize Vit C due to lack of what?

A

L-gulonolactone oxidase

22
Q

Palatal ostium in GPs

A

Soft palate is contiuous with tongue, causing small hole - palatal ostium

23
Q

Unique cytology

A

Predominant WBCs
Heterophils
Kurloff cells

24
Q

What are Kurloff cells?

A

Estradiol-dependent mononuclear leukocyte

Help prevent maternal rejection during pregnancy - form barrier in placenta

25
Q

What is unique about GP distal bronchi?

A

Most prominent smooth muscle compared to other mammals

26
Q

Which cells are abundant in GP lungs?

A

Mast cells, eos

27
Q

What’s unique about GP pulmonary arteries?

A

Marked thickening of media

Surrounded by prominent concentric bands of smooth muscle

28
Q

Excess dietary cholesterol leads to what in GPs?

A

Acute hemolytic anemia

29
Q

What’s unique about GP renal arteries?

A

2-3 pairs supply each kidney

30
Q

GP uterus

A

Bicornuate, single cervix

31
Q

Why should females be bred <6mos of age?

A

To prevent dystocia from pelvic symphysis

32
Q

Preyer response

A

Pinna tilts rearwards with sharp sounds

Used in otologic research

33
Q

Why are GPs used in research?

A

Long gestation period with mature neuro systm at birth
Large TB
Nutritional characteristics

34
Q

Buehler test

A

Compound applied to skin topically 3x followed by challenge

35
Q

GPs are used to study which herpesvirus?

A

HSV2 (simplex)

36
Q

Sereny test

A

Assay for bacterial invasiveness - organisms placed in conjunctival sac, leading to development of keratoconjunctivitis

37
Q

Suborder of hamsters

A

Myomorpha

38
Q

Syrian/golden hamster g/s

A

Mesocricetus auratus

39
Q

Chinese/grey hamster g/s

A

Cricetulus griseus

40
Q

European/black-belled hamster g/s

A

Cricetus cricetus

41
Q

Armenia/migratory hamster g/s

A

Cricetulus migratorius

42
Q

Djungarian, Siberian, Dwarf, striped hairy footed hamster g/s

A

Phodopus sungorus

43
Q

Lifespan of hamsters

A

1.2-2 years

44
Q

Avg litter size of hamsters

A

5-10

45
Q

Gestation period for hamsteres

A

15-16 days

46
Q

How are hamster cheek pouches unique?

A

Lack lymphatic drainage pathways - immunologically privileged

47
Q

Flank glands of hamsters develop neoplasia when what happens?

A

With simultaneous stimulation by androgens and estrogens

48
Q

Which strain of hamster is used for cardiomyopathy?

A

Strain BIO 14.6

49
Q

Hamsters were the first animal model for Cushing’s or Addison’s?

A

Addison’s

50
Q

Application of what to hamster cheek pouches causes SCC?

A

DMBA

51
Q

Hamster cheek pouches are ideal for what kind of graft?

A

Xenograft without rejection

Yale Residency - Rabbits, Guinea Pigs, Misc. Rodents (18 decks)

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