9-Adrenergic Drug

Question 1

selective direct acting adrenergic agonists (4)

Answer 1

A1 - phenylephrine
A2- clonidine
B2- terbutaline
D1- fenoldopam

Question 2

nonselective direct acting adrenergic agonists (5)

Answer 2

B1/2- isoproterenol
B1/2A1- dobutamine
A1/2 B1/2- epi
A1/2B1- NE
D1/2A1- dopa

Question 3

direct acting adrenergic drugs are _____- by prior treatment with reserpine or guanethidine

Answer 3

not reduced!

Question 4

mix ating adrenegic agonist (1)

Answer 4

ephedrine (A1/2B1/2)

Question 5

ephedrine response is_____ by prior treatment with reserpine or guanethidine

Answer 5

reduced

Question 6

indirect acting releasing agents adrenergic agonists (2)

Answer 6

amphetamine

tyramine

Question 7

indirect acting releasing agents adrenergic agonists responses are ____________ by prior treatment with reserpine or guanethidine

Answer 7

abolished by

Question 8

indirect acting uptake inhibitor adrenergic agonist (1)

Answer 8

cocaine

Question 9

indirect acting MAO/COMT inhbitors adrenergic receptor (2)

Answer 9

pargyline

entacapone

Question 10

clinical indications for phenylephrine

Answer 10

anithypotensive
paoxysmal atrial tachycardia

nasal decongestant
mydriatic

Question 11

MOA for clonidine and alpha methyldopa

Answer 11

activate central a2 receptors and decrease central sympathetic outlflow to decrease BP

Question 12

MOA for apraclonidine and brimonidine

Answer 12

decrease aquesous humor production and decrease intraocular pressure

Question 13

adverse effects of alpha 2 slective adrenergic receptor agonists

Answer 13

dry mouth
sedation
hypotension

Question 14

therapeutic use for metaproterenol

Answer 14

long term lung conditions

*resistant to methylation by COMT

Question 15

albuterol

Answer 15

main use for bronchospasm

Question 16

specific use as a uterine relaxant

Answer 16

ritodrine

arrests premature labor and prolongs pregnancy

Question 17

what increases risk of adverse cardio effects with B2 agonists?

Answer 17

MAO inhibitors

degredation of compound would decrease

Question 18

clinical use of fenoldopam

Answer 18

hypertensive crisis

D1 receptor agonist

Question 19

clinical uses of isoproterenol

Answer 19

bradycardia
AV block
torsades de pointes

Question 20

mainly acts on B1 receptors at therapeutic dose

Answer 20

dobutamine

Question 21

acute MI - want to increase performance - use?

Answer 21

dobutamine

because increase contraction without increasing HR too much

Question 22

stress test for people who can’t run etc.

Answer 22

use dobutamine to stimulate heart working out