13- GI I Flashcards
what does the parietal cell secrete?
- HCL (prtn digestion, sterilization, nutrient absorption)
- Intrinsic Factor (vitamin B12 absorption)
what does the chief cell secret?
Pepsinogen (prtn digestion)
what does the superficial epithelial cell secrete?
Mucus and bicarbonate (gastroprotection)
what does the ECL secrete?
Histamine (promote HCl secretion)
what does the G cell secrete?
gastrin (promote HCl secretion)
What is the role of Ach in stomach mucosa?
- promote mucus secretion
- promote bicarb secretion
- promote HCl secretion
what do D cells secrete?
Somatostatin (suppress HCl secretion)
3 roles of prostaglandins
- mucus and bicarb secretion
- suppress HCL secretion
- Increased gastric blood flow
2 most common causes ulcers in US
NSAIDS and h. pylori infection
why does h. pylori cause infection?
inhibits cyclooxygenase which thereby blocks prostaglandin formation
common adverse effects of anatacids
reduced drug bioavailability due to pH changes
enteric infection risk increase (also due to pH changes)
fastest antacid
sodium bicarb
adverse effects sodium bicarb
- metabolic alkalosis
- excessive NaCl absorption
- gas/bloating
specific adverse effects calcium carb
- acid rebound
- gas/bloating
specific adverse effects magnesium hydroxide
osmotic diarrhea
specific adverse effects aluminimun hydroxide
constipation
common adverse effect of H2 receptor antagonists
headache
specific adverse effects cimetidine
- CNS (confusion , hallucinations, agitation)
- Endocrine (could lead to gynecomatia)
- inhbit CYP metabolism (drug-drug interactions)
key role for prostaglandins
- mucus and bicarb secretion
- suppression ofHCL secretion
- increasedd gastsric blood flow
prostaglandin analogue acid-peptic disease treatment option
misoprostol
what agent would you use to treat acid-peptic disease and the patient is hospitalized?
sucralfate
standard of treatment for h. pylori ulcers
"new triple therapy" PPI clarithromycin amoxicillin metronidazole
