8- Cholinoceptor blocking drugs Flashcards
muscarinic receptor antagonists (3)
atropine
ipratropium
benztropine
nicotinic receptor antagonist (2)
hexamethonium
mecamylamine
non-depolarizing neuromuscular blocking drugs (1)
d-tubocurarine
depolarizing neuromuscular blocking drugs
succinylcholine
effects of atropine in order of increasing doses
*binds to all M receptors
decreased secretions mydriasis and cycloplegia hyperthermia tachycardia sedation urinary retention and constipation behavioral excitation and hallucinations (because can enter CNS)
atropine ___________ peripheral vasodilation caused by choline esters but _________ blood pressure when given alone
counteracts
does not affect
clinical use of atropine
management of AchE inhibtor overdose
antidiarrheal
prevent vagal reaction in some procedures (pericardiocentesis)
what do you use as a antidote for atropine overdose?
physostigmine
effects of ipratropium
decrease bronchoconstriction
decreased bronchial secretions
first line therapy for COPD
inhalaed ipratropium
second line thearpy for flares /asthma
ipratropium inhaled
used to reestablish dopamingergic-cholinergic balance in patients with parkinsons disease
benztropine (has CNS absorption)
second or third line therapy for parkinsons or secondary to antipsychotic for parkinsons
benzotropine
ganglion blocking agents
hexamethonium and mecamylamine
block the predominate system
no longer available clincially because of toxicities
used primarily as adjuncts during general anesthesia to facilitate intubation and surgical condition
neuromuscular blocking drugs
- don’t go to CNS
