8- Adregnergics

Question 1

rate limiting enzyme of catecholamine synthesis

Answer 1

tyrosine hydroxylase

Question 2

fermented cheese?

Answer 2

increases tyramine which can lead to an increase in NE by different pathway

Question 3

what blocks tyrosine hydroxylase?

Answer 3

metyrosine

Question 4

where does synthesis of dopa –> NE happen?

Answer 4

in storage vesicles enter with VMAT

Question 5

what does reserpine block?

Answer 5

VMAT

this will decrease blood pressure

Question 6

what facilitates catecholamine release and what blocks this facilitator?

Answer 6

VAMP which is inhibited by bretylium

Question 7

what inhbits the reuptake of NE via NET?

Answer 7

cocaine, tricyclic antidepressants

this can lead to MI

Question 8

what metabolizes NE?

Answer 8

mitochondrial monoamine oxidase MAO

Question 9

Gq ->_____ ->

Answer 9

phospholipase C –> increased Ca2+ and PKC activation

Question 10

receptor that are Gq

Answer 10

histamine1, alpha1, vanilliod, M1 and M3,

Question 11

receptors that are Gs

Answer 11

B1 B2 D1 H2 V2

Question 12

Gs –> _______ –>

Answer 12

adenylyl cyclase –> increased PKA activity

Question 13

receptors that are Gi

Answer 13

MAD 2

M2 alpha2 and D2

Question 14

Gi –I _______ –>

Answer 14

inhibits adenyly cyclase –> decreased PKA

Question 15

Nn and Nm receptors –>

Answer 15

activation of Na/K channels

Question 16

A1 radial muscle in eye –>

Answer 16

contraction - mydriasis

Question 17

A1 arterioles –>

Answer 17

contraction –> increased resistance –> increased diastolic pressure –> increased afterload

Question 18

A1 veins –>

Answer 18

increased contraction –> increased venous returen –> increased preload

Question 19

A1 bladder trigone and sphincter –>

Answer 19

contraction –> urinary retention

Question 20

A1 male sex organ –>

Answer 20

vas deferens –> ejacualtion

Question 21

A1 liver –>

Answer 21

glycogenolysis

Question 22

A1 kidney –>

Answer 22

decreased renin release

Question 23

A2 prejunctional nerve terminal –>

Answer 23

decreased NT release and NE synthesis

Question 24

A2 platelets –>

Answer 24

aggregation

Question 25

A2 pancreas –>

Answer 25

decreased insulin secretion

Question 26

B1 SA node –>

Answer 26

increased HR

Question 27

B1 AV node —>

Answer 27

increased conduction velocity

Question 28

B1 heart muscle –>

Answer 28

increased force of contraction, CO,

Question 29

B1 purkinje fiber –>

Answer 29

increased automaticity

Question 30

B1 kidney –>

Answer 30

increased renin release

Question 31

B2 blood vessel –>

Answer 31

vasodilation

Question 32

B2 uterus –>

Answer 32

relaxation

Question 33

B2 bronchioles –>

Answer 33

dilation

Question 34

B2 skeletal muscle –>

Answer 34

increased glycogenolysis, increased contractility (tremor)

Question 35

B2 liver –>

Answer 35

increased glycogenolysis

Question 36

B2 pancreas –>

Answer 36

increased insulin secretion

Question 37

D1 peripheral –>

Answer 37

vasodialtion

in kidney –> increased GFR, RBF and Na excretion

Question 38

increase total peripheral resistance (increase alpha 1) –>

Answer 38

reflex bradycardia

the exact opposite is also true

decrease TPR with decrease alpha1 –> reflex tachycardia