8- Adregnergics Flashcards
rate limiting enzyme of catecholamine synthesis
tyrosine hydroxylase
fermented cheese?
increases tyramine which can lead to an increase in NE by different pathway
what blocks tyrosine hydroxylase?
metyrosine
where does synthesis of dopa –> NE happen?
in storage vesicles enter with VMAT
what does reserpine block?
VMAT
this will decrease blood pressure
what facilitates catecholamine release and what blocks this facilitator?
VAMP which is inhibited by bretylium
what inhbits the reuptake of NE via NET?
cocaine, tricyclic antidepressants
this can lead to MI
what metabolizes NE?
mitochondrial monoamine oxidase MAO
Gq ->_____ ->
phospholipase C –> increased Ca2+ and PKC activation
receptor that are Gq
histamine1, alpha1, vanilliod, M1 and M3,
receptors that are Gs
B1 B2 D1 H2 V2
Gs –> _______ –>
adenylyl cyclase –> increased PKA activity
receptors that are Gi
MAD 2
M2 alpha2 and D2
Gi –I _______ –>
inhibits adenyly cyclase –> decreased PKA
Nn and Nm receptors –>
activation of Na/K channels
A1 radial muscle in eye –>
contraction - mydriasis
A1 arterioles –>
contraction –> increased resistance –> increased diastolic pressure –> increased afterload
A1 veins –>
increased contraction –> increased venous returen –> increased preload
A1 bladder trigone and sphincter –>
contraction –> urinary retention
A1 male sex organ –>
vas deferens –> ejacualtion
A1 liver –>
glycogenolysis
A1 kidney –>
decreased renin release
A2 prejunctional nerve terminal –>
decreased NT release and NE synthesis
A2 platelets –>
aggregation
A2 pancreas –>
decreased insulin secretion
B1 SA node –>
increased HR
B1 AV node —>
increased conduction velocity
B1 heart muscle –>
increased force of contraction, CO,
B1 purkinje fiber –>
increased automaticity
B1 kidney –>
increased renin release
B2 blood vessel –>
vasodilation
B2 uterus –>
relaxation
B2 bronchioles –>
dilation
B2 skeletal muscle –>
increased glycogenolysis, increased contractility (tremor)
B2 liver –>
increased glycogenolysis
B2 pancreas –>
increased insulin secretion
D1 peripheral –>
vasodialtion
in kidney –> increased GFR, RBF and Na excretion
increase total peripheral resistance (increase alpha 1) –>
reflex bradycardia
the exact opposite is also true
decrease TPR with decrease alpha1 –> reflex tachycardia
