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Pharm > 9 - Adrenergic Agents > Flashcards

9 - Adrenergic Agents Flashcards

1
Q

Adrenegic agents

A

Drugs that mimic or enhance actions of EP or NE

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2
Q

Direct acting agents

A

Activate adrenegic recptores

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3
Q

Indirect acting agents

A

No direct receptor actions
CAT inhibitors
monamine oxidase inhibitors

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4
Q

Adrenolitic agents

A

Block NE/EP actions

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5
Q

Chemical properties of catecholamines

A

Catechol ring

Oxidized in room air

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6
Q

Catecholamine drugs

A

Dopamine
Norepi.
Epin.
Isoproterenol

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7
Q

Properties of catecholamines

A

Not well absorbed
Rapid onset
Short duration
Enzymatic degradation

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8
Q

Two families of adrenegic receptors

A

Alpha

Beta

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9
Q

What receptors does Epi have a stronger action on

A

Beta

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10
Q

Norepi has stronger action on what receptors

A

Alpha

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11
Q

Where are alpha receptors located

A

Visceral organs

CNS

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12
Q

A1 effects

A

Increased PI formation

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13
Q

A2 effects

A

Decreased cAMP formation

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14
Q

Phenylephrine receptors

A

Alpha agonist

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15
Q

Beta receptor effects

A

Increase cAMP

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16
Q

Beta 1/2 agonist

A

Isoproterenol

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17
Q

What mediates EP and NE effects

A

B1 receptors in cardiac tissues

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18
Q

What effect do Symp drugs have on the heart

A

Increase: rate, contractility, conduction velocity

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19
Q

How do B1 receptors work

A

Via G protien mediated activation of adrenal cyclist with increased production of intracellular cAMP

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20
Q

Target of Symp stimulation on blood vessels

A

Vascular smooth muscle cell

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21
Q

Sympathetic effect on blood vessels

A

Pressor response
Increase mean arterial pressure
opposing actions by B and A receptors

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22
Q

A1 receptor on blood vessel

A

Increase blood receptor

Constriction

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23
Q

B2 receptor on blood vessels

24
Q

Cardiovascular actions of NE depend on

A

What receptor

25
A1 stimulation NE
Increased: systolic, diastolic, and mean arterial pressures Decreased: Heart rate
26
Why does NE stimulation with a1 receptor cause a decrease in HR
Barroreceptors
27
Isoproterenol works on what receptors
Beta
28
Effect of Isoproterenol on B2
Decrease: blood pressure vasodilation Increase: heart rate, cardiac output
29
EP acts on
A2 and B1&2 receptors
30
EP low dose
B2: Vasodilation B1: increase HR., cardiac output
31
EP high dose
B1: Increase HR (can cause arrhythmia) B1 & A1: systolic vasoconstriction A1: diastolic vasoconstriction
32
Eye a1 agonist
Pupil dilation
33
Lungs B2 agonists
Enhanced secretion Relaxation Used in inhalers
34
Lungs a1 agonist
Reduced secretion (predominates)
35
GI B1
Reduce motility
36
GI a1
Constrict sphincter
37
Bladder b1
Relax fundis
38
Bladder a1
Constict sphincter
39
Sweat glands
Goofy as shit
40
Uses of alpha adrenegic agonists
Maintain blood pressure Reduce localized bleeding Nasal decongestants Emetic effect in cats
41
Phenylephrine
Increase BP Acute pressor -Management of shock Stimulates a1&2
42
Phenylephrine adverse effects
Bradycardia Excitation/nervous PE + atropine = increased BP and tachycardia Extravasation injury
43
A adrenegic antagonists uses
acute reduction in BP Urinary tract disorders (relaxes) Reversal of Xylazine induced depression
44
Side effects of alpha blocker
``` Postural hypotension GI irritability Stuffiness Impotence Sedation and depression ```
45
A- adrenergic antagonists
Phentolamine Phenoxybenzamine Yohimbine Atipamezole
46
Use of B adrenergic agonists
``` B1: Acute treatment of cardiac failure B2: Respiratory difficulty and bronchial asthma -short term Delay parturition B1/2: allergic reactions ```
47
Uses for a adrenergic agonists
Hemostasis Nasal decongestant Raise BP Adjuncts to local anesthetics
48
Isoproterenol
B1/2 | Cardiac stimulation
49
Terbutaline
B2 Treat asthma No stimulation of heart
50
B adrenergic agonists uses
Increase: HR, Cardiac contraction Conduction through AV node (B1) Smooth muscle relaxation (B2)
51
What does the magnitude of effects produced by adrenegic drugs depend on
Sympathetic activity
52
Primary use for B antagonists
Cardiac effects Long term control of systemic hypertension Anti arrhythmic Heart failure
53
Propranolol
B1/2 Antiarrhythmic Must be withdrawn gradually IV
54
Atenolol
B1 blocker Anti arrhythmic
55
Esmolol
B1 blocker

Pharm (15 decks)

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