8 - ANS Flashcards
Preganglionic sympathetic neurons release
Actylcoline
Post ganglion sympathetic neurons release
Norepinephrine
Reserpine
Long lasting
Inhibits vesicular monamine transporter
Horses
What makes the adreanal gland different
No postganglionic neurons
Release both epi and norepi
What makes the sweat gland different in the ANS
Sweat gland releases acetylcholine for both Preganglionic and postganglionic
A1 receptor
Gp
Smooth muscle
Causes contraction
Epinephrine>norepi>isoproterenol
What causes one drug to have multiple effects
Different receptors
B1 receptors
Heart
Contraction
Isoproterenol>epi>norepi
Pre synaptic receptors
important in CNS
Control transmitter release
Parasympathetic neurons release
Acetylcholine for both pre and postganglion
What happens if you inhibit Ach synthesis
DEATH
How is Ach eliminated
Enzymatic
What is the major post synaptic receptor target for drugs
M3
Pharmacological antagonism
Blockade of an agonist by an antagonist
Physiological antagonism
Opposing actions produced by two drugs via actions on different receptors or via distinct mechanisms
