9/27/11

Question 1

In order for a drug to mainly metabolized and excreted by the liver, rather than the kidneys, what property is essential? Would that cause the drug to have a high or low Vd?

Answer 1

lipophilicity; high Vd

Question 1

Describe the type of epithelium that lines most of the respiratory tract (including the trachea and bronchi, nasal sinuses, pharynx, and laryngeal vestibule).

Answer 1

pseudostratified, columnar, mucus secreting epithelium

Question 2

Why shouldn’t vitamin B6 be taken by parkinson’s pts?

Answer 2

it enhances the peripheral metabolism of levodopa

Question 3

What H2 antagonist can cause gynecomastia?

Answer 3

Cimetidine (“She’s a brick house.”)

Question 4

Basophilic clusters on the surface of intestinal mucosal cells in an AIDS patient (CD4<180)

Answer 4

Cryptosporidium (non-bloody diarrhea)

Question 5

The ventral posteromedial nucleus (VPM) of the thalamus receives input from the _______ and _______ pathways.

Answer 5

trigeminal and gustatory