9/26/12 Flashcards
Chronic lymphedema predisposes to what tumor?
angiosarcoma
Which hepatits virus causes hepatocytes to take on a finely granular, eosinophilic “ground glass” appearance? What are the granules?
HBV; HBsAg
Which hepatitis virus is characterized by lymphoid aggregates in the portal tracts and macrovesicular steatosis?
HCV
5-HIAA is a breakdown product of _______ used to screen for _______.
5-HT; carcinoid tumors
Tryptase is released by what cells?
Mast cells
Hemophilia B is an XR defect of Factor __.
IX
Bilateral acoustic neuromas.
NF-2
Lisch nodules and cafe-au-alit spots.
NF-1
Cerebellar hemangioblastomas, retinal hemangiomas, and liver cysts.
Von Hippel-Lindau disease
Mode of inheritance of Von Hippel-Lindau disease? Associated kidney condition?
AD; renal cell carcinoma
Facial port-wine stain and leptomeningeal angioma.
Sturge-Weber syndrome
What is the inheritance pattern of Sturge-Weber syndrome?
Trick question! Sturge-Weber is the result of an embryological malformation – not heritable!
Recurrent epistaxis or GI bleeding due to multiple telangiectasias of the skin and mucosa.
hereditary hemorrhagic telangiectasia (aka Osler-Weber-Rendu syndrome)
What is the inheritance pattern of tuberous sclerosis?
AD
Please label the following structures.
A. II
B. optic chiasm
C. optic tract
D. III
E. IV
F. V
G. VI
H. VII
I. VIII
J. IX
K. XII
L. X
M. XI
Serologically, what differentiates a person who was vaccinated against HBV from one who had the infection, but recovered?
absence of anti-HBcAg IgG
What HBV serological marker of infection is present in the “window period” between disappearance of HBsAg and appearance of anti-HBsAg?
anti-HBcAg IgM
What does HBeAg really indicate? What does its presence for more than 3 mos indicate?
active viral replication and high infectivity; probable chronic infection
How is HBV carrier state defined (serologically)?
HBsAg in serum for >6 mos
Benign condition w/ elevated conjugated bilirubin levels.
Dubin-Johnson (or Rotor’s) syndrome
Benign condition w/ elevated unconjugated bilirubin levels.
Gilbert ‘s syndrome
What enzyme is totally absent in Crigler-Najjar syndrome and may be deficient in Gilbert’s syndrome?
UDP-glucuronyltransferase
Name the left heart pathology.
aortic stenosis
Name the left heart pathology.
mitral insufficiency
Name the left heart pathology.
aotic insufficiency
Name the left heart pathology.
mitral stenosis
