8.2 Pathophysiology of Pneumonia Flashcards
Provide a simple definition of pneumonia
Acute infection of the pulmonary parenchyma
How many hospital admissions for pneumonia per year in Australia?
77,000
Pneumonia was the ___th leading cause of death in Australia in 2019
9th
List some risk factors for pneumonia
- Age > 65
- Chronic lung disease (e.g. COPD, cystic fibrosis)
- Immunocompromised conditions (e.g. HIV)
- Lifestyle factors (smoking, alcohol, toxic inhalation of substances)
Additional important questions to ask during history of suspected TB patient
- Living environment
- Current/previous employment
- Travel and emigration
- Sick contacts
- Toxic exposures
- Vaccinations
Symptoms of pneumonia
- Productive cough
- Dyspnoea
- Pleuritic chest pain
- Lethargy
Signs of pneumonia
- Tachypnoea
- Fever
- Tachycardia
- Hypoxia
- Dullness to percussion
- Decreased breath sounds
- Bronchial breathing
- Coarse crackles
Describe the SMART COP mnemonic for pneumonia severity
- Systolic BP <90mmHg
- Multilobar CXR involvement
- Albumin < 3.5 g/dL
- Resp Rate >30
- Tachycardia >125bpm
- Confusion
- O2 sats <90%
- pH <7.35
Explain the CURB-65 severity scoring
- Confusion
- Urea >7 mmol/L
- Respi rate >30
- Blood pressure (sys <90 or dia <60)
- Age: >65
List some acute complications of pneumonia
- Sepsis
- Parapneumonic effusion
- Empyema
- Respiratory failure
What is parapneumonic effusion?
Accumulation of fluid in pleura due to inflammatory response to pneumonia
What is empyema?
Direct infection/pus buildup in pleural space
How is community acquired pneumonia transmitted (mechanism of transport)?
Droplets/aerosols
Describe the pathophysiology of community acquired pneumonia (starting with transmission)
- Droplets/aerosols
- Colonise nasopharynx
- Microaspiration -> parenchyma
- If macrophage cannot contain, it releases cytokines
- Systemic and local inflammatory response
Aetiological classifications of pneumonia
- Bacterial
- Viral
- Aspiration
- Atypical
- Opportunistic