8.1 ISBT 007 (Lewis) Flashcards
Lewis is not synthesized by RBC but from the ________ which is _________ by ____________
Plasma
Adsorbed
RBC membrane
Lewis is frequently found in?
Pregnant women
Lewis is Enzyme resistant
T or F
T
Frequency of lewis:
Newborn: Le (a_, b_)
-, -
Frequency of lewis:
Shortly after birth: Le (a_, b_)
+,-
What type of chain on the RBC is where secretion is located?
Type 1 precursor
Which of the following converts type 1 precursor into Le^a?
Le or Se
Le
Which of the following converts type 1 precursor adding an H?
Le or Se
Se
Type 1H
In Type 1H:
Converting Type 1H with Le results to?
Le^b
In Type 1H:
Converting Type 1H with A gene to?
A Le^b
In Type 1H:
Converting Type 1H with B gene to?
B Le^b
Shortly after birth what Le is more predominant?
Le^a [Le (a+, b)]
Shortly after birth: Homozygous Le (a)
T or F
T
After 10 days from birth: What Le is more predominant?
Le (a+, b+)
After 10 days from birth: Heterozygour Le
T or F
T
More than 6 yrs old, what Le is more predominant?
Le (a-, b+)
Newborns have more Le than Se
T or F
F
Le (a-, b-)
Shortly after birth: Le is lesser than Se
T or F
F
Greater
After 10 days, Le is equal to Se
T or F
T
After 6 years, Le is greater than Se
T or F
F
Lesser
Lewis is located on what chromosome?
Chrom 19
Genes: Le, Se, A/B/H
Ag in Secretion: ?
RBC phenotype: A/B/H, Le (a-, b+)
A/B/H, Le^b
Genes: lele, Se, A/B/H
Ag in Secretion: A/B/H, None
RBC phenotype: A/B/H, _________
Le (a-, b-)
Genes: Le, se, A/B/H
Ag in Secretion: ________, _________
RBC phenotype: A/B/H, _________
NO A/B/H, Le^a
Le (a+, b-)
Genes: le, se, A/B/H
Ag in Secretion: ________, _________
RBC phenotype: ______
None
ABH
Genes: Le, se, A/B
Ag in Secretion: ________, _________
RBC phenotype: ________, _________
NO A/B/H, Le^a
Oh, Le(a+, b-)
What blood group antigen is associated with peptic ulcer?
Le^b
Le^b is a receptor fr what bacteria?
H.pylori
What lewis INCREASED SUSCEPTIBILITY to Candida and Uropathogenic E.coli?
Le (a-,b-)
Le^x is a marker for?
Reed-Sternberg cell
Hallmark of Hodgekin’s lymphoma
Reed-Sternberg cell
(Owl’seye appearance)
