8.1 ISBT 007 (Lewis)

Question 1

Lewis is not synthesized by RBC but from the ________ which is _________ by ____________

Answer 1

Plasma

Adsorbed

RBC membrane

Question 2

Lewis is frequently found in?

Answer 2

Pregnant women

Question 3

Lewis is Enzyme resistant

T or F

Answer 3

T

Question 4

Frequency of lewis:

Newborn: Le (a_, b_)

Answer 4

-, -

Question 5

Frequency of lewis:

Shortly after birth: Le (a_, b_)

Answer 5

+,-

Question 6

What type of chain on the RBC is where secretion is located?

Answer 6

Type 1 precursor

Question 7

Which of the following converts type 1 precursor into Le^a?

Le or Se

Answer 7

Le

Question 8

Which of the following converts type 1 precursor adding an H?

Le or Se

Answer 8

Se

Type 1H

Question 9

In Type 1H:

Converting Type 1H with Le results to?

Answer 9

Le^b

Question 10

In Type 1H:

Converting Type 1H with A gene to?

Answer 10

A Le^b

Question 11

In Type 1H:

Converting Type 1H with B gene to?

Answer 11

B Le^b

Question 12

Shortly after birth what Le is more predominant?

Answer 12

Le^a [Le (a+, b)]

Question 13

Shortly after birth: Homozygous Le (a)

T or F

Answer 13

T

Question 13

After 10 days from birth: What Le is more predominant?

Answer 13

Le (a+, b+)

Question 14

After 10 days from birth: Heterozygour Le

T or F

Answer 14

T

Question 15

More than 6 yrs old, what Le is more predominant?

Answer 15

Le (a-, b+)

Question 16

Newborns have more Le than Se

T or F

Answer 16

F

Le (a-, b-)

Question 17

Shortly after birth: Le is lesser than Se

T or F

Answer 17

F

Greater

Question 18

After 10 days, Le is equal to Se

T or F

Answer 18

T

Question 19

After 6 years, Le is greater than Se

T or F

Answer 19

F

Lesser

Question 20

Lewis is located on what chromosome?

Answer 20

Chrom 19

Question 21

Genes: Le, Se, A/B/H
Ag in Secretion: ?
RBC phenotype: A/B/H, Le (a-, b+)

Answer 21

A/B/H, Le^b

Question 22

Genes: lele, Se, A/B/H
Ag in Secretion: A/B/H, None
RBC phenotype: A/B/H, _________

Answer 22

Le (a-, b-)

Question 23

Genes: Le, se, A/B/H
Ag in Secretion: ________, _________
RBC phenotype: A/B/H, _________

Answer 23

NO A/B/H, Le^a

Le (a+, b-)

Question 24

Genes: le, se, A/B/H
Ag in Secretion: ________, _________
RBC phenotype: ______

Answer 24

None

ABH

Question 25

Genes: Le, se, A/B
Ag in Secretion: ________, _________
RBC phenotype: ________, _________

Answer 25

NO A/B/H, Le^a

Oh, Le(a+, b-)

Question 26

What blood group antigen is associated with peptic ulcer?

Answer 26

Le^b

Question 27

Le^b is a receptor fr what bacteria?

Answer 27

H.pylori

Question 28

What lewis INCREASED SUSCEPTIBILITY to Candida and Uropathogenic E.coli?

Answer 28

Le (a-,b-)

Question 29

Le^x is a marker for?

Answer 29

Reed-Sternberg cell

Question 30

Hallmark of Hodgekin’s lymphoma

Answer 30

Reed-Sternberg cell

(Owl’seye appearance)