5.1 ISBT 004 (Rh Blood Group) Flashcards
Rh Blood Group comes from What chromosome?
Chromosome 1
Rh Blood group is ___ most important Blood group
2nd
Rh antigen is discovered from?
Rhesus Monkey
Rh Antibody was discovered from?
Guinea pig and Rabbit
Chromosome # for MNS?
4
1st Case related to Rh Blood Group includes Acute Hemolytic Transfusion Reaction from pregnant woman
T or F
T
Order of Immunogenicity in Rh group?
D > c > E > C >e
Theory of Multiple Allelomorphic genes occuring at a SINGLE Chromosomal Loci
Wiener Theory
Theory of pairs of Linked Gene, the antigens of the system were produced by THREE CLOSELY linked sets of Alleles
Fisher Race
▪ D gene -> D antigen
▪ C/c gene -> C/c
▪ E/e gene -> E/e
What Theory is this?
Fisher Race Theory
Rh genes -> Rho, rh’, rh”
What theory is this?
Wiener Theory
What is the Shorthand designation for Rho?
Ro
What is the Shorthand designation for rhy?
ry
What is the Wiener Agglutination for Rh1
Rh1
What is the Fisher Race Antigens for Rhz
DCE
What is the Fisher Race Antigens for rhy?
CE
What is the Fisher Race Antigens for rh”?
cE
What is the Fisher Race Antigens for Rh1?
DCe
What is the Fisher Race Antigens for rh?
ce
What is the Wiener Blood factors for Rh1
Rho rh’ hr”
What is the Wiener Blood factors for Rhz?
Rho rh’ rh”
What is the Wiener Blood factors for rh”?
hr’ rh”
What is the Wiener Blood factors for rhy?
rh’ rh”
What is the Rosenfield for Rho?
1, -2, -3, 4, 5
What is the Rosenfield for Rhz?
1, 2, 3, -4, -5
What is the Rosenfield for rh”?
-1, -2, 3, 4, -5
What is the Rosenfield for rh?
-1, -2, -3, 4, 5
What is the Rosenfield for Rh2?
1, -2, 3, 4, -5
What is the Rosenfield name if the mother “DCE” and the father “dce”?
1, 2, 3, 4, 5
● Mother = DCE/DcE
● Father = dCe/dce
Which of the following is not an offspring?
a. r/Rz
b. R2/r
c. Rz/r
d. Rz/R2
d
Which genotype is heterozygous for “C”
a. Ro / R1
b. r / r”
c. R1/Rz
d. R2 / r”
a
If a patient develops anti-“c”, what is the genotype?
“C”
Which donor unit is selected if the recipient has anti-“c” and Anti-“e”?
a. Ro
b. R1
c. R2
d. Rz
d
Genetics for Rh are inherited as codominant alleles
T or F
T
Genetic Weak D has a weak D with no antibodies created
T or F
T
Parenthesis such as (D), (C), (E), indicates strong antigens
T or F
F
Weark
C trans is position effect is where one genotype has capital C while the other is small c
T or F
T
PArtial D (D mosaic) is where parts of “D” is Missing which creates antibodies
T or F
T
What is the Test for Weak D or Partial D?
Indirect Antiglobuin test
Reporting: A+
Ab screening: Anti D negative
a. Partial D
b. Genetic weak D
b
Reporting: A+
Ab screening: Anti D Positive
a. Partial D
b. Genetic weak D
a
An emergency situation where an Indirect antiglobulin test will not be possible at the moment, what blood type should you release after blood typing these 2?
a. O+
b. O-
b
In Reporting:
If the patient has weak D, how should you report for Rh?
Negative
In Reporting:
If the Donor has weak D, how should you report for Rh?
Positive
In HDFN :
Mother = D _
Fetus = D _
-
+
In HDFN:
When the mother is in labor, the uterus will be teared causing the baby RBCs (with Rh positive) to enter the blood stream of the mother causing to create anti-D
T or F
T
Anti-D is IgM
T or F
F
IgG
IgG is warm reacting
T or F
T
In HDFN:
When Anti-D sensitize with Fetal RBC, the RBC will pop
T or F
F
The Sensitized Fetal RBC will TRY to enter the splenic filter of the fetus but is instead eaten by the macrophage
HDFN is intravascular hemolysis
T or F
F
Extravascular hemolysis
How to extract fetal blood for testing of fetal blood?
Cordocentesis
HDFN has complement activation
T or F
F
No complement activation
HDFN occurs when mother is _______ and the fetus is_____
D-
D+
The possibility of the 1st born to have HDN if:
- The mother has Anti-D due to transfusion
- Abdominal trauma the lead to destruction of placenta
T or F
t
What are the HDN antibodies?
Anti-Kell (K)
Anti-Duffy (a)
