2.1 ISBT 001 (Major Blood Group System) Flashcards

1
Q

ISBT means?

A

International Society of Blood Transfusion

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2
Q

What is the blood group for ISBT 001?

A

ABO Blood group System

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3
Q

What are the Major Blood group?

A

ABO and Rh

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4
Q

Immunogen Evoke Immune response

T or F

A

T

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5
Q

All Immunogens are antigens but not all antigens are immunogens

T or F

A

T

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6
Q

First Person to do Forward and Reverse typing?

A

Karl Landsteiner

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7
Q

Most Immunogenic blood group and most important?

A

ABO

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8
Q

ABO is the only blood group with NATURALLY occuring antibody without prior exposure

T or F

A

T

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9
Q

Foundation to pre-transfusion testing?

A

ABO compatibility

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10
Q

What type of antibody that is naturally occuring and more predominant during agglutination / ABO?

A

IgM

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11
Q

Wrong ABO transfusion is the leading cause of death in Hemolytic transfusion Reaction (HTR)

T or F

A

T

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12
Q

What chromosome creates H and Se Genes?

A

Chromosome 19

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13
Q

What chromosome creates ABO Genes?

A

Chromosome 9

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14
Q

Term for does not produce DETECTABLE antigen?

A

Amorph

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15
Q

Also known as Silent Gene?

A

Amorph

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16
Q

What are the Silent Genes?

A

Jk
O
Lu

(Silent JkOL)

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17
Q

All RBC has Type II chain

T or F

A

T

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18
Q

what are the GLycosyl transferase?

A

L-fucosyl transferase
N-acetylgalactosaminyl transferase
D-Galactosyl transferase

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19
Q

Glycosyl transferase for H gene?

A

L-fucosyl transferase

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20
Q

Glycosyl transferase for B gene?

A

D-galactosyl transferase

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21
Q

Glycosyl transferase for A gene?

A

N-acetylgalactosaminyl transferase

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22
Q

Glycosyl transferase for AB gene?

A

N-acetylgalactosaminyl transferase
D-galactosyl transferase

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23
Q

Glycosyl transferase enzyme catalyzes the TRANSFER of immunodominant sugar to the Type I chain on the RBC

T or F

A

F

Type II chain

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24
Q

A sugar that occupies the terminal position of the Type II chain (At the end)

This indicates the ABO blood type

A

Immunodominant Sugar

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25
Greatest Amount of H to Least?
O, A2, B, A2B, A1, A1B
26
Least amount of H to Greatest?
A1B, A1, A2B, B, A2, O
27
Surface Ag and Plasma Ab for O?
No surface antigen, Anti A and Anti B
28
Surface Ag and Plasma Ab for A?
A, Anti B
29
Surface Ag and Plasma Ab for B
B, Anti-A
30
Surface Ag and Plasma Ab for AB
AB, No Antibody
31
universal Donor?
O
32
Universal Reciever?
AB
33
Highest Incidence to Lowest for ABO blood group?
O, A, B, AB
34
Forward and Reverse typing is phenotyping or Genotyping?
Phenotyping
35
Forward typing uses a commercial known ________ of known specificity
Antisera (Antibody)
36
The antisera use for Forward typing is Polyclonal T or F
F Monoclonal
37
What is the specimen use for Forward typing?
RCS (Red Cell suspension) / RBC
38
Forward typing detects antibody T or F
F Antigen on RBC surface
39
Dye for Anti A Reagent?
Blue
40
Dye for Anti B Reagent?
Yellow
41
Dye for Anti D Reagent?
Clear
42
What is the Reaction for both Forward and Reverse typing?
Agglutination
43
Term for Binding of RBC and Antibody?
Sensitization
44
Term for binding of sensitized RBC and antibody
Latice formation
45
Forward typing Known A: 4+ Known B: 0
A
46
Forward typing Known A: 0 Known B: 4+
B
47
Forward typing Known A: 0 Known B: 0
O
48
Forward typing Known A: 3+ Known B: 3+
AB
49
Backward typing is also known as Slide typing T or F
F Tube typing
50
Backward typing uses what reagent?
2-5% RBC suspension
51
Serum contains RBC T or F
F
52
Backward typing uses how many tubes?
3 KA, KB, KO
53
Backward typing detects the presence of?
Antibodies (IgM)
54
What is the Specimen used for Backward typing?
Serum
55
Both Forward and Reverse are done at What temp?
Room Temp
56
What antibody is being detected in Room temp?
IgM
57
Most common ABO RCS?
O
58
Backward typing: Known A cell: O Known B cell: 4+
A
59
Backward typing: Known A cell: 4+ Known B cell: 0
B
60
Backward typing: Known A cell: O Known B cell: O
AB
61
Backward typing: Known A cell: 4+ Known B cell: 4+
O