8 - Small Intestine Path

Question 1

normal villous to crypt length ratio

Answer 1

3-5 : 1

Question 2

80% of mechanical obstruction of small intestine are caused by what 4 things?

Answer 2

hernias
intestinal adhesions
intussusception
volvulus

Question 3

sx of intestinal obstruction

Answer 3

abd pain
distention
vomiting
constipation

Question 4

causes of intussusception in infants/young children and adults

Answer 4

infants/ young kids - rotavirus

adults - intraluminal mass/tumor

Question 5

signs of ischemic bowel disease

Answer 5

diminished bowel sounds
rigid abdomen
pain

Question 6

genes assoc w/ celiac

Answer 6

HLA-DQ2, HLA-DQ8

Question 7

clinical features of celiac in adults

Answer 7

anemia, chronic diarrhea, bloating, chronic fatigue

Question 8

clinical features of celiac in kids

Answer 8

irritability, abd distention, anorexia, chronic diarrhea, failure to thrive, wt loss, muscle wasting

less common - abd pain, nausea, vomiting, bloating, constipation

Question 9

what do you need to r/o before you can trust neg celiac serology?

Answer 9

IgA deficiency

Question 10

micro path of celiac

Answer 10

atrophic/absent villi <1 crypt : villi

inc T lymphocytes

Question 11

whipple’s disease

Answer 11

intestinal lipodystrophy due to tropheryma whippelli
can have systemic involvement
large macrophages crowding lamina propria, distorting villi
presentation w/ triad of diarrhea, wt loss, malabsorption