15 - IBD Flashcards
2 bacteria which may contribute to IBD
mycobacteria paratuberculosis
enteroadherent E coli
gene assoc w/ Crohn’s dz
NOD2
related to immune response to bacteria - innate immune system
what is a protective gene mutation against IBD?
IL23 receptor
who gets IBD?
young white adults mostly - equal M/F
how do you determine severity of ulcerative colitis
number of stools/day, amount of bleeding, signs of toxicity
2 endoscopy hallmarks of Crohn’s
“punched out” aphthae
longitudinal ulcers
systemic complications of IBD
aphthous stomatitis, uveitis, arthritis, erythema nodosum, pyoderma gangrenosum, vascular complications (thromboembolic), sclerosing cholangitis, cholangiocarcinoma
which systemic complications are more common with each type of IBD?
UC - primary sclerosing cholangitis, pyoderma gangrenosum
CD - ankylosing spondylitis, erythema nodosum
long term sequela of UC
colorectal cancer incidence of ~10%
which IBD is more likely to cause adhesions, fistulae, and obstructions?
Crohn’s
