Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ALI > 8. Fat Metabolism > Flashcards

8. Fat Metabolism Flashcards

1
Q

Triacylglycerols

A

cytoplasm of ADIPOSE cells

1 glycerol, 3 FAS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Hormonal promoters of lipolysis

A

Norepinephrine

Epinephrine

Glucagon

Adrenocorticotropic hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Fate of Glycerol

A

taken up by liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Deficiency of carnitine or translocase

A

Muscle cramps

severe weakness

death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

β-oxidation of a saturated Fatty Acid

A

Step wise degradation of 2C elements

Releases:

FADH2

NADH

Acetyl CoA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The Peroxisome

A

A secondary site for fatty acid oxidation

shortens long chain FAs

Better substrate for mitochondria uptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Zellweger Syndrome

A

No functional peroxisomes

Liver, kidney and muscle abnormality

Early death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Synthesis Of Fatty Acids

A

Occurs In The Cytosol

Acetyl CoA + oxalacetate (4C) = citrate (6C)

citrate transported out

Formation Of Malonyl CoA

Acetyl CoA + Malonyl CoA transferred to ACP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The LDL receptor

A

Prevents uptake of additional cholesterol

Expression regulated by SREBP transcription factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Loss of LDL receptor

A

Familial hypercholesterolemia

Blood cholesterol levels ↑

Leading to arterial narrowing

CHD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Deficiencies in LCAT and CETP

A

Prevents formation of cholesterol esters

free blood cholesterol accumulates in various tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Deficiencies in Apo E receptor

A

Can’t remove CM/VLDL remnants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Clinical management of Homozygous (FHC)

A

Liver transplant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Clinical management of Heterozygous FHC

A

Lower Cholesterol levels in diet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Chylomicron (CM)

A

fat & cholesterol from intestine

Ends up in adipose tissue to store fat

Ends up in liver for removal as a CM remnant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Very light Density Lipoprotein (VLDL)

A

Transports Fat from liver to Adipose tissue

Ends up back at liver as a VLDL remnant or converts to LDL

17
Q

Light Density Lipoprotein (LDL)

A

Transports cholesterol to peripheral tissues

18
Q

High Density lipoprotein (HDL)

A

transports chol from tissues to liver for removal

19
Q

ApoB48

A

found on CMs

Structural function

20
Q

ApoB100

A

On VLDLs and LDL

Targets LDLs to peripheral tissues

21
Q

ApoC-II

A

Found on CMs & VLDLs, obtained from HDLs

Activates Lipoprotein lipase

22
Q

ApoE

A

Found on CMs & VLDLs, obtained from HDLs

Targets CMs & VLDLs to liver for disposal

23
Q

ApoA1

A

Found on HDLs

Activates LCAT

24
Q

LDL-R

A

Binds Apo100 targeting LDLs to peripheral cells

25
Q

Lipoprotein lipase

A

Found on surface of capillaries

insulin responsive activity

Hydrolyses TAG in CMs and VLDLs for transport into adipose tissue

26
Q

ACAT + LCAT

A

Esterify cholesterol

27
Q

SR-B1

A

Found on liver

Interacts with HDL

deposit cholesterol into hepatic cells

28
Q

CETP

A

Pumps cholesterol from HDLs to VLDLs

29
Q

ABCA1

A

found on surface of peripheral cells

pumps out cholesterol to HDLs

ALI (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions