8 Design of pain medication Flashcards
1
Q
how do nsaids work
A
they bind to enzyme cox and reduce prostaglandin synthesis
2
Q
how does aspirin work
A
irreversibly inhibits cox1
prevents platelet aggregation
3
Q
what does a benzene ring mean in regards to action length
A
makes them act longer
4
Q
where does ibuprofen come from
A
propionic acid
5
Q
where does diclofenac come from
A
acetic acid
6
Q
examples of selective COX inhibitors
A
- celecoxib
- parecoxib
- etoricoxib
7
Q
does paracetamol inhibit cox
A
basically no
only works at huge huge amounts
8
Q
do ndsaids have similar physiochem properties and structures
A
yes
9
Q
why is aspirin unique
A
it binds irreversibly with cox1
