6 receptor pharmacology Flashcards
what does agonist quanification allow
comparison of EC50 values
what does it mean if EC50 values are low
the drug is more potent
what activates full and partial agonists
saturating endogenous ligand
what activates neutral and inverse agonists
receptor activity in absence of the ligand
what is pharmacological antagonism
when drugs counteract each other by acting on the same receptor type
what is chemical antagonism
when one drug antagonises the action of another by chemically combining with it
how do you reverse competitive antagonism
by increasing agonist concentration
what is irreversible competitive antagonism
when the bond between the antagonist and receptor is so strong that increasing agonists has no effect
usually due to covalent bonding
what are non competitive antagonists
antagonists which act at sites other than the agonist binding site
can antagonists and agonists have the same physiological effect
yes, depending on receptor location
what does physiological response depend on (voltage gated channels)
ion permeability
what is a G protein coupled receptor
a signalling pathway that’s activation depends on G-protein coupling
why are GPCRs so important
- involved in numerous physiological processes
- target for >50% of all prescribed meds
