16 targets for antiemetics and how this relates to drug design

Question 1

what causes nausea and sickness

Answer 1

chemical or neurological signals in the body

usually a small molecule binding to receptor which causes a normal but undesirable effect

Question 2

structure of receptor

Answer 2

a-helix, beta sheets etc

Question 3

what are receptors created from

Answer 3

amino acids which form a poly-peptide
(N-terminal to carboxyl and numbered in sequence)

Question 4

what makes the specific binding interactions between messengers

Answer 4

the constituent amino acid side chains, leads to activation

Question 5

are benzene rings lipophilic

Answer 5

yes

Question 6

is NH2 polar or non polar

Answer 6

polar

Question 7

are COOH (carboxylic acids) polar or non polar

Answer 7

polar

Question 8

what are the receptor-ligand interactions

Answer 8

• H-bond binding region
• ionic binding region
• van-der-waals and pipi binding region

Question 9

what does the H-bond binding region do

Answer 9

make the molecule more hydrophilic

Question 10

vdW region and pi pi region characteristics

Answer 10

non-polar, relatively weak

Question 11

do all the binding regions work together

Answer 11

yes, basis of biological key and lock

Question 12

can the structure of the molecule affect where in the active site it binds

Answer 12

yes due to different binding reactions