725 Neurotransmitters Flashcards
Dopamine’s 3 primary functions
reward pathway (motivation), pleasure, cognition (attention), voluntary movement
Two primary locations of dopamine
substantial nigra and VTA (ventral tegmental area)
What tract does the substantial nigra form and what is controlled by dopamine using this tract?
nigrostriatal tract; motor control
If the nigrostriatal tract is injured what disorder occurs?
Parkinson’s
What two systems come from the VTA?
mesocortical and mesolimbic
Cocaine blocks reuptake in what dopamine system?
mesolimbic
Dopamine is ___________ in schizophrenia.
elevated
Dopamine is ____________ in ADHD.
decreased
Decreased dopamine causes brain ____, mood _____, and muscle _______.
brain fog, mood swings, and muscle spasms
Increased dopamine causes __________, difficulty with ________ control, _________, insomnia/excessive ________, and ______________.
anxiety/aggression, difficulty with impulse control, euphoria, insomnia/excessive energy, and hallucinations.
Dopamine imbalance is implicated in what two disorders?
SUD and schizophrenia
DOPAMINE stands for what effects?
Drug addiction
Outcomes (motivation/goals)
Psychosis (w/too much)
Attention (determines what gets attention)
Movement (Parkinson’s)
Inhibition of prolactin
Nausea
Energy
What dopamine pathway is responsible for negative symptoms of schizophrenia?
mesocortical
Catecholamine breakdown is catalyzed by what, from inside the cells?
MAO
If you block dopamine (reduce) you ______ positive symptoms via the _______________ pathway.
block; mesolimbic
Where is NE primarily located?
locus ceouleus