725 Antidepressant "Book" Flashcards
What antidepressant class is very effective for depression but rarely used?
MAOI
Why are MAOI’s “last resort”?
HIGH potential for toxicity and lethal in ODs
Mechanism of action of MAOI’s/what neurotransmitters involved?
IRREVERSABLY destroys MAO (enzyme that breaks down neurotransmitters) in synaptic cleft which INCREASES 5-HRT, NE, & DA availability.
Uses of MAOIs?
Atypical depression
SEs of MAOIs?
Anticholinergic/antihistamine effects (xerostomia, drowsiness, dizziness, lightheadedness), nausea, diarrhea/constipation, HTN CRISES!
MAOI’s have ________ of drug to drug interactions and have ________ w/drawl effects.
a lot; severe
Do not take with SSRI/SNRIs due to risk of ___________ ___________ risk; wait for __ to __ wks after d/c’ing to start one.
serotonin syndrome; 2-5 wks
What MAOI is selective w/DA only and is sometimes used in Parkinson’s treatment?
selegiline (Emsam)
DO NOT consume what when taking MAOIs, why?
tyramine foods (aged foods like cheese & wine); combination can cause HTN crises (life threatening)
What group of antidepressants are typically used in primary care for things other than mental health conditions?
Tricyclics
Tricyclic antidepressants are ___________ in the treatment of depression w/high remission rates BUT have ________ of SEs and are highly ____________ in an OD.
effective; many; lethal
If rx’ing tricyclic antidepressants to someone w/SI/high risk, how long a rx should you write?
1 week
Mechanism of action of tricyclics that is COMPLEX; what does this COMPLEX mechanism cause?
blocks transporters site for 5-HRT & NE AND is an antagonist @ histamine, muscarinic Ach, & alpha-adrenergic receptors; which causes many SEs
Uses for tricyclics?
depression
anxiety, OCD, PTSD
pain syndromes
nocturnal enuresis
Most common SE of tricyclics? Other SEs?
orthostatic hypotension; lightheadedness*
confusion/delirium (especially w/dementia)
anticholinergic effects: sedation, xerostomia, constipation*, urine retention, blurred vision, CONFUSION
many cardiovascular effects: arrythmia
renal failure
n/v, hyperhidrosis
seizures, fine-rapid tremors, twitches of tongue/upper extremities
Although SEs, tricyclics are less likely to cause these compared to SSRIs/SNRIs
sexual dysfunction, weight gain, sleep disturbances
Most common reason tricyclic antidepressants are d/c’d?
orthostatic hypotension
What year was SSRIs first available in US?
1980
Compared to older antidepressants SSRIs have less potential for?
lethal OD
Mechanism of SSRIs?
stops re-uptake of 5-HRT into synaptic cleft which increased the amount of 5-HRT which increases the ability of post-synaptic neuron to fire -or- increases sensitivity of post synaptic receptors
SSRIs used for?
depression
GAD, OCD, PTSD
eating DOs
Most common SEs of SSRIs? Other SEs?
decreased ability to orgasm/ejaculate;
agitation, anxiety/panic
sleep disturbances, nighttime rapid muscle movements
n/v, stomach cramps, diarrhea
some QT elongation/multiple interactions
SEs of SSRIs are typically?
self-limiting
SSRIs take about ___ wks to take effects though SEs are seen prior; they take _____ wk for full effect
2; 4-6