72. Carcinogenesis (biological agents) Flashcards
Microbial carcinogenes
Fungi (mycotoxins)
Plants
Oncogenic viruses
Due to host protooncogenic activity, uncontrolled oncoprotein production is induced in the virus (cell proliferation) example of virus
retroviruses
Viral oncogenes example
papillomaviruses
Without own viral oncogenes, the viruses can insert into host genome, and activate oncoprotein production
example?
avian leukosis virus
RNA-viruses as carcinogenes example
retroviruses
RNA-viruses 2 groups:
Contains oncogenes (v-onc) or transformation genes
Lack of v-onc
direct Oncogenic DNA-viruses
primarily actives c-onc
indirect Oncogenic DNA-viruses
cease the cell’s apoptotic potential, inactivate
tumorsuppressor genes
Spiprocerca lupi can be the cause of…
Parasite induced carcinogenesis