70. Tumor-induced angiogenesis

Question 1

Vasculogenesis

Answer 1

bone marrow derived endothelial cells form new
vascular network

Question 2

Neovascularisation

Answer 2

new vessel budding

Question 3

Why is Neoangiogenesis for the tumor

Answer 3

 Without angiogenesis, tumours can’t grow bigger than 1-2 mm (diffusion distance)
 Need of oxygen, nutrients and removal of metabolits
 The new vessels’ endothelial cells produce growth factors also (IGF,
PDGF, GM-CSF)
 Opportunity of metastasis

Question 4

From what Antiangiogenic factors are made?

Answer 4

produced by the split of plasminogene, collagene and transthyretin

Question 5

Antiangiogenic factors examples

Answer 5

 Angiostatin
 Endostatin
Vasculostatin

Question 6

newly formed vessels from tumors are

Answer 6

abnormal, Permeable, dilated, and distorted

Question 7

Lymphangiogenesis

Answer 7

Already existing lymphatic vessels are proliferating (effect of VEGF)
Inevitable for solid tumours’ metastasis to lymph nodes