67. Definition of tumor (oncogenes, tumorsuppressor genes) Flashcards
1
Q
Neoplasma, neoplasia
A
new tissue proliferation
2
Q
What does an inactivation of tumorsuppressor genes result in
A
Resistence to growth inhibitors
3
Q
Telomerase activity
A
enzyme, which adds TTAGGG oligonucleotides to 3’ end of chromosome’s telomer
4
Q
outcome of Telomerase activity
A
immortalisation
5
Q
Main targets of carcinogenesis
A
Protooncogenes
Oncogenes
Suppressor genes
Stability genes
6
Q
Protooncogenes:
A
normal genes, produced metabolits aid cell
proliferation
7
Q
Oncogenes:
A
mutant or highly expressed variants of protooncogenes, their function is autonomous, don’t need normal growth signals
8
Q
Suppressor genes:
A
inhibit cell proliferation through regulation of cell-cycle
