7-1 and 8-1 (perman done)

Question 1

read: hint for remembering acquired disorders of mito = they all are caused by a direct effector

• Reye (person)
• cyanide (chemical)
• monoxide (chem)

Know which are INHERITABLE by comparing with ACQUIRED

Answer 1

-

Question 2

purine contain # rings; which nucleotides are purines

pyrimidines contain # rings; “”

Answer 2

2; A, G

py - 1; C and U-RNA or T-DNA

Question 3

in nucleotide, what is the backbone

Answer 3

pentose monosaccharide

Question 4

nucleoside vs tide

Answer 4

side-purine/pyrimidine is attached to pentose sugar

tide-side + phosphate groups

Question 5

purine/pyrimidine base is attached to pentose sugar at # C to form nucleoside

Answer 5

1 C

Question 6

phosphate groups are attached at # C

Answer 6

5 C

Question 7

salvage pathway: use existing bases without de novo synthesis

(purine/pyrimidine) are salvaged

Answer 7

PURINE

Question 8

IMP -> AMP or GMP

AMP synthesis requires (GTP or ATP)

opp for other

Answer 8

AMP syn req GTP

Question 9

Describe purine and pyrimidine’s REL to PRPP

Answer 9

Purine is assembled ON PRPP

Pyrimidine: ring is synthesized separately
Once finalized, it is attached to PRPP

Question 10

PRPP synthase is inh by what

Answer 10

purine

Question 11

porphyrin structure

Answer 11

4 linked pyrrole rings (read: tetrapyrrole)

Question 12

how are porphyrin dist from each other

Answer 12

by side groups

Question 13

what is the most abundant tetrapyrrole in vertebrates

Answer 13

heme

Question 14

structure of heme

Answer 14

Fe in center of tetrapyrrole ring

read: binds 02, C02, CO

Question 15

formation of tetrapyrrole steps

Answer 15

amino-le-vulinate is dimerized
product is tetramerized
= tetrapyrrole

Question 16

read: Shemin ate glycine, bled himself at regular intervals, isolated the heme

learned about heme

Answer 16

-

Question 17

heme N atoms are derived from which AA

another building block of heme

Answer 17

glycine

succinyl coA

Question 18

heme in RBC have half life of # days

Answer 18

120 d

Question 19

heme is produced in what organs

Answer 19

liver

bone marrow

Question 20

compon of hemoglobin

Answer 20

1-4 chains (two alpha, two beta)

2-one heme per chain

Question 21

UV fluorescent in urine is caused by what reacnt in heme synthesis rxn

Answer 21

Protoporphyrin 4

Question 22

most common porphyrias

Answer 22

porphyria cutanea tarda

Question 23

RBC are degraded where

Answer 23

spleen and liver

Question 24

r: most heme that is degraded comes from mature RBC

Answer 24

-

Question 25

blood/cellular iron is complexed to ferritin

Answer 25

cellular only

Question 26

heme synthesis in bone marrow (NOT LIVER) has a variable/constant rate production

Answer 26

constant

Question 27

we know that liver’s cytoc P450 is related to heme but HOW specifically

Answer 27

cytoc must consume heme to detoxify

Question 28

unconjugated vs con - dif in looks

Answer 28

con looks more complicated

Question 29

how many glycines per heme

Answer 29

8 glycines

Question 30

what causes the symptoms associated with jaundice

Answer 30

accumulation of bilirubin

Question 31

GENERAL jaundice is characterized by what physio symptoms

Answer 31

yellow

• skin
• nail
• sclera (white part of eyeball)

Question 32

hemoglobin transports 02

what does myoglobin do

Answer 32

stores 02

Question 33

purpose of conjugation for bilirubin

where does con happen

Answer 33

make it water soluble

in liver