6-Raynaud Disease

Question 1

what is Raynaud disease

Answer 1

functional vasculopathy of unkown origin

Question 2

how is raynaud disease characterized

Answer 2

sudden vasoconstriction of peripheral arteries of the extremities and other acral parts

Question 3

what factors lead to sudden vasoconstriction in Raynauds disease

Answer 3

exagerrated response to stimuli such as temperature or emotional upset

Question 4

what is the effet of sudden vasoconstriction

Answer 4

fingers change color in sequence:

• white (pallor)
• blue (cyanosis)
• red (reactive hyperemia)

Question 5

what is hyperemia

Answer 5

presence of an increased amt of blood in a region or organ

Question 6

why do tissues turn white, then blue, then red during sudden vasoconstriction

Answer 6

white–lack of blood
blue–vessels dilate to keep blood in tissue
red-blood flow returns

Question 7

is there permanent damage in raynaud disease

Answer 7

no, very rare–digits might become smooth and shiny with loss of tissue and muscle

Question 8

what happens histologically to blodd vessels in advanced cases of Raynauds disease

Answer 8

thickened arterial intima and thrombosis in small arteries

Question 9

what is Raynaud phenomenon

Answer 9

this is Raynaud disease PLUS an underlying arterial disease such as atherosclerosis, SLE, scleroderma, Buerger disease

Question 10

is Raynauds more common in men or women

Answer 10

more common in women (60-90%)

Question 11

what is another name for Raynaud disease

Answer 11

Idiopathic Raynauds phenomenon