12-Pathogenesis of Atherosclerosis Flashcards
1
Q
when does atherosclerosis usually begin
A
about 10 yrs old
2
Q
chronic endothelial injuries are due to what
A
- hyperlipidemia
- hypertension
- smoking
- homocysteine
- hemodynamic factors
- toxins
- viruses
- immune reactions
3
Q
what are the processes in response to injury (stages of atherosclerotic development
A
1–chronic endothelial injury
2–endothelial dysfunction
3–smooth muscle emigration from media to intima. macrophage activation
4-macrophages and smooth muscle cellls engulf lipid
5-smooth muscle proliferation, collogen deposition, EC lipid
4
Q
what initiates the pathogenesis of atherosclerosis
A
development of focal regions of chronic endothelial injury
5
Q
what initiates endothelial dysfunction in early atherosclerosis
A
- hemodynamic disturbances
- adverse effect of high cholesterol
