6-Osteodystrophy unknown causes

Question 1

What is Paget’s disease?

Answer 1

accelerated resorption and deposition of bone, osteoblasts win and bones become sclerotic, larger and brittle; white male, polyostotic

Question 2

How does Paget’s disease appear radiographically?

Answer 2

cotton wool-like radiopacity, generalized hypercementosis

Question 3

Complications of Paget’s disease?

Answer 3

fracture, malignant transformation, 1% develop osteogenic carcinoma

Question 4

What is Fibrous Dysplasia?

Answer 4

Starts a large cascade and eventually cAMP, affects differentiation of proteoblasts, prolonged activation stimulates endocrine receptors, bones become replaced with fibrous tissue and immature bone

Question 5

Fibrious dysplasia monostotic or polyostotic?

Answer 5

Monostotic

Question 6

What is Jaffe-Lichtenstein Syndrome?

Answer 6

Fibrous dysplasia polyostotic with cafe au lait spots

Question 7

What is McCune-Albright Syndrome?

Answer 7

Fibrous dysplasia polyostotic with cafe au lait AND endocrinopathy

Question 8

Clinical features of Fibrous dysplasia?

Answer 8

Young - 1-2 decades
Long bone pain/fracture
Craniofacial expansion/disfigurement
CFFD = Compress vital structures
Like optic nerve - blindness

Question 9

Clinical features of McCune-Albright Syndrome?

Answer 9

Hyperendocrine function such as gonads

Question 10

Radiographic appearance of Fibrous dysplasia?

Answer 10

early lesions lucent->mixed->ground glass opacity

Question 11

Fibrous dysplasia treatment?

Answer 11

FD stabilizes so bad ones recontour

Question 12

General characteristics of Central Giant Cell Granuloma?

Answer 12

Females
Before age 30 - young
Md 70%
Anterior jaws
classically crossed midline

Question 13

Describe nonaggressive Central Giant Cell Granuloma?

Answer 13

asymptomatic, slow growth, nor cortical perforation or root resorption

Question 14

Describe aggressive Central Giant Cell Granuloma?

Answer 14

Pain, rapid growth, cortical perforation and root resorption

Question 15

Radiographic appearance of Central Giant Cell Granuloma?

Answer 15

unilocular/multilocular
noncorticated margins
cortical perforation or expansion
root resorption

Question 16

What is an Aneurysmal bone cyst?

Answer 16

intraosseous accumulation of variable-sized, blood-filled spaces surrounded by cellular fibrous tissue with giant cells

Question 17

Aneurysmal bone cyst features?

Answer 17

in long bones/vertebrae
children and young adults
rapid swelling
pain

Question 18

Radiographic appearance of an aneurysmal bone cyst?

Answer 18

radiolucent
multilocular
cortex expanded, thinned or perforated
borders well defined or diffuse

Question 19

Who does Idiopathic Osteosclerosis affect?

Answer 19

Blacks
Chinese
Japanese

Question 20

Where does Idiopathic Osteosclerosis occur?

Answer 20

90% Md
1st molar
contacts tooth root 80%

Question 21

Idiopathic Osteosclerosis easily confused with?

Answer 21

Condensing Osteitis

but tooth is VITAL

Question 22

Radiographic appearance of Idiopathic Osteosclerosis?

Answer 22

well defined radiopacity
blends
contacts tooth root
can make diagnosis off clinical/radiograph findings

Question 23

Treatment for Idiopathic Osteosclerosis?

Answer 23

86% stabilize so no Tx

Question 24

What is Focal Osteoporotic Bone Marrow Defect?

Answer 24

asymptomatic radiolucent lesion in middle age females secondary to low grade anemia perhaps

Question 25

Where does Focal Osteoporotic Bone Marrow Defect occur?

Answer 25

Md 70%

Question 26

Radiographic appearance of Focal Osteoporotic Bone Marrow Defect?

Answer 26

radiolucent

fine internal trabeculation

Question 27

Treatment for Focal Osteoporotic Bone Marrow Defect?

Answer 27

incisional biopsy
no Tx
may stimulate other diseases