6-Osteodystrophy unknown causes Flashcards
What is Paget’s disease?
accelerated resorption and deposition of bone, osteoblasts win and bones become sclerotic, larger and brittle; white male, polyostotic
How does Paget’s disease appear radiographically?
cotton wool-like radiopacity, generalized hypercementosis
Complications of Paget’s disease?
fracture, malignant transformation, 1% develop osteogenic carcinoma
What is Fibrous Dysplasia?
Starts a large cascade and eventually cAMP, affects differentiation of proteoblasts, prolonged activation stimulates endocrine receptors, bones become replaced with fibrous tissue and immature bone
Fibrious dysplasia monostotic or polyostotic?
Monostotic
What is Jaffe-Lichtenstein Syndrome?
Fibrous dysplasia polyostotic with cafe au lait spots
What is McCune-Albright Syndrome?
Fibrous dysplasia polyostotic with cafe au lait AND endocrinopathy
Clinical features of Fibrous dysplasia?
Young - 1-2 decades Long bone pain/fracture Craniofacial expansion/disfigurement CFFD = Compress vital structures Like optic nerve - blindness
Clinical features of McCune-Albright Syndrome?
Hyperendocrine function such as gonads
Radiographic appearance of Fibrous dysplasia?
early lesions lucent->mixed->ground glass opacity
Fibrous dysplasia treatment?
FD stabilizes so bad ones recontour
General characteristics of Central Giant Cell Granuloma?
Females Before age 30 - young Md 70% Anterior jaws classically crossed midline
Describe nonaggressive Central Giant Cell Granuloma?
asymptomatic, slow growth, nor cortical perforation or root resorption
Describe aggressive Central Giant Cell Granuloma?
Pain, rapid growth, cortical perforation and root resorption
Radiographic appearance of Central Giant Cell Granuloma?
unilocular/multilocular
noncorticated margins
cortical perforation or expansion
root resorption
What is an Aneurysmal bone cyst?
intraosseous accumulation of variable-sized, blood-filled spaces surrounded by cellular fibrous tissue with giant cells
Aneurysmal bone cyst features?
in long bones/vertebrae
children and young adults
rapid swelling
pain
Radiographic appearance of an aneurysmal bone cyst?
radiolucent
multilocular
cortex expanded, thinned or perforated
borders well defined or diffuse
Who does Idiopathic Osteosclerosis affect?
Blacks
Chinese
Japanese
Where does Idiopathic Osteosclerosis occur?
90% Md
1st molar
contacts tooth root 80%
Idiopathic Osteosclerosis easily confused with?
Condensing Osteitis
but tooth is VITAL
Radiographic appearance of Idiopathic Osteosclerosis?
well defined radiopacity
blends
contacts tooth root
can make diagnosis off clinical/radiograph findings
Treatment for Idiopathic Osteosclerosis?
86% stabilize so no Tx
What is Focal Osteoporotic Bone Marrow Defect?
asymptomatic radiolucent lesion in middle age females secondary to low grade anemia perhaps
Where does Focal Osteoporotic Bone Marrow Defect occur?
Md 70%
Radiographic appearance of Focal Osteoporotic Bone Marrow Defect?
radiolucent
fine internal trabeculation
Treatment for Focal Osteoporotic Bone Marrow Defect?
incisional biopsy
no Tx
may stimulate other diseases
