5th Biochemistry Lecture Exam (Batch 2024) Flashcards
- Which active lipase acts on diacylglycerol in the lipid droplet?
A. Adipose triacylglycerol lipase
B. Hormone sensitive lipase
C. Monoacylglycerol lipase
D. Colipase
Hormone sensitive lipase
- Which is the major pathway of the oxidation process?
A. Mitochondrial beta
B. Alpha
C. Omega
D. Peroxisomal
Mitochondrial beta
- Beta oxidation occurs in almost all tissues
EXCEPT:
A. Erythrocytes
B. Hepatocytes
C. Muscle cells
D. Myocardiocytes
Erythrocytes
- What molecule activates fatty acids prior to transport into the matrix?
A. Carnitine
B. Coenzyme A
C. Coenzyme Q
D. Acyl carrier protein
Coenzyme A
- How many moles of high energy phosphate compounds are hydrolysed in the activation of fatty acids?
A. 1
B. 2
C. 3
D. 4
2
- What drives the activation reaction of fatty acids to completion?
A. Formation of the acyl adenylate moiety
B. The release of the AMP
C. Hydrolysis of the PPi by inorganic phosphatase
D. Nucleophilic attack by the sulphur atom of CoA
Hydrolysis of the PPi by inorganic phosphatase
- Which protein transports the palmitoyl carnitine inside the matrix?
A. Carnitine acyl carnitine translocase
B. Tricarboxylate translocase
C. Monocarboxylate translocase
D. Dicarboxylate translocase
Carnitine acyl carnitine translocase
- What are the four reactions, in the order of occurrence, which are carried out every time a two carbon moiety is removed from a fatty acid being oxidized?
A. Cleavage, hydration, oxidation, oxidation
B. Oxidation, cleavage, oxidation, hydration
C. Oxidation, hydration, oxidation, cleavage
D. Hydration, oxidation, cleavage, oxidation
Oxidation, hydration, oxidation, cleavage
- What complex of the ETC accepts the electrons and protons coming from the first reaction of beta oxidation?
A. NADH-CoQ oxidoreductase
B. ETFP-CoQ oxidoreductase
C. Cytochrome c oxidase
D. Cytochrome oxidase
NADH-CoQ oxidoreductase
- Which enzymes catalyze the third reaction of beta oxidation?
A. Acyl CoA dehydrogenase
B. Thiolase
C. Enoly CoA hydratase
D. 3-L-hydroxyacylCoA dehydrogenase
3-L-hydroxyacylCoA dehydrogenase
- How many ATPs does the second reaction of beta oxidation generates after transferring its electrons and protons to the ETC?
A. 2
B. 3
C. 4
D. 5
3
- How many cycles/spirals would a 16 carbon saturated fatty acid undergo in beta oxidation releasing the acetyl CoA moieties?
A. 5
B. 6
C. 7
D. 8
7
- How many ATPs are generated from all the acetyl CoA moieties released from beta-oxidation of palmitic acid?
A. 90
B. 93
C. 96
D. 98
108
- What is the product of the last cycle/spiral of beta oxidation of a 17 carbon saturated fatty acid aside from acetyl CoA?
A. Acetyl CoA
B. Isobutyryl CoA
C. Propionyl CoA
D. Valeryl CoA
Propionyl CoA
- To what intermediate of the TCA cycle does the product of the last cycle/spiral of beta-oxidation of odd-chain fatty acid enter?
A. Fumarate
B. Succinyl-CoA
C. Succinate
D. Malate
Succinyl-CoA
- What additional enzyme is used in the beta oxidation of a monounsaturated fatty acid?
A. ∆3∆2-enoyl CoA isomerase
B. 2,4-dienoyl CoA-reductase
C. Enoyl CoA-reductase
D. Acyl CoA dehydrogenase
Acyl CoA dehydrogenase
- How many ATP less would be derived from oxidation of a monounsaturated fatty acid compared with the oxidation of a saturated fatty acid having the same number of carbons?
A. 4
B. 3
C. 2
D. 1
2
- Which oxidation process is used to degrade very long chain fatty acids?
A. Mitochondrial beta
B. Alpha
C. Omega
D. Peroxisomal
Mitochondrial beta
- How would the products of oxidation of VLCFA generate energy in the form of ATP?
A. Have to be transported to the mitochondrial matrix
B. Thru the glycolytic pathway
C. Metabolized thru the alpha oxidation
D. Degraded via the omega oxidation
Have to be transported to the mitochondrial matrix
- More ATPs are formed per cycle/spiral thru mitochondrial beta oxidation than thru oxidation of VLCFA, by how many?
A. 1
B. 2
C. 3
D. 4
4
- Which of the following characterize arachidonic acid?
A. ω-3 polyunsaturated
B. Contains C18
C. Cis configurations
D. 4 double bonds at 5, 8, 12, 14
Cis configurations
- Eicosanoids are not construed by:
A. Found in structural lipids
B. Synthesized from ω-3 FAs
C. Synthesized from ω-6 FAs
D. Synthesized from monounsaturated FAs
Synthesized from ω-3 FAs
- Classic eicosanoids:
A. Contains 2 double bonds and 4 double bonds
B. Derived from eicosapentaenoic acid
C. ω-6 series derived from AA
D. Requires phospholipase A
ω-6 series derived from AA
- Prostanoids and leukotrienes derived from eicosapentaenoic acids:
A. Prostanoids have 3 double bonds
B. Leukotrienes have 4 double bonds
C. Prostanoids have 2 double bonds
D. Leukotrienes have 6 double bonds
Leukotrienes have 4 double bonds