5 intro to clinical pharmacokinetics Flashcards
What is pharmacokinetics?
The study of drug movement in and out of the body
What is bioavailability?
The fraction of administered dose that is absorbed into the systemic circulation
What does volume distribution depend on?
Physicochemical characteristics
How do you calculate Cmax?
F x dose / V
How do you calculate IV loading dose?
Target Cpeak x V
How do you calculate oral loading dose?
Target Cpeak x V/F
How do you calculate volume of distribution?
F x dose/ Cpeak
What is clearance?
The volume of plasma cleared of drug per unit time
how to calculate Cpeak
Dose/Volume
how to calculate steady state Caverage clearance
(FxDose) / (CLxt)
CL= clearance
how to calculate clearance
FxDose / CavSSx t
triangle with DCV
D
C V
triangle with steady state etc
DR
CssAV. CL
DR= dose rate
CssAV = conc average steady state
CL = clearance
