15 drug metabolism Flashcards
1
Q
What does the prefix ‘nor-‘ indicate`?
A
N-dealkylation has occurred
2
Q
What does the prefix ‘des-‘ indicate?
A
A group has been removed
3
Q
What do FMO’s do?
A
Oxidise nitrogen
4
Q
What are esters hydrolysed by?
A
Esterases
5
Q
What are amides hydrolysed by?
A
Amidases
6
Q
Which is more polar glucoronic acid or glucose?
A
glucoronic acid
7
Q
What does glutathione conjugation do?
A
Detoxify electrophiles of phase I metabolites
8
Q
How are phase II metabolites excreted?
A
Hepatocytes contain active transporters that recognise polar molecules so the metabolite enters the bile and leaves in faeces.
