5 Flashcards
scientific study of disease
pathology
cause of diseaese
Etiology
manner in which disease develops
pathogenesis
disease-causing microorganism
pathogen
invasion or colonization of the body
by pathogenic microorganisms
infection
any change from a state of health
due to infection
disease
subjective changes not apparent
to an observer
symptoms
objective changes the physician can
observe and measure
signs
a specific group of symptoms or
signs that may always accompany a particular
disease
syndrome
microorganisms that establish more or less
permanent residence (colonize) but that do not
produce disease under normal conditions
normal microbiota
prevention of overgrowth of harmful microorganisms by normal microbiota
microbial antagonism
One organisms benefits, and other is unaffected
commensalism
both organism benefit
mutualism
one organism benefits at the expense of the other
parasitism
ordinarily do not cause disease in their normal
habitat in a healthy person but may do so in a
different environment
opportunistic pathogen
demonstrated that Bacillus anthracis was always
present in the blood of animals that had the
disease (anthrax) and not in healthy animals
Robert Koch
did the same for Mycobacterium tuberculosis
(Koch’s bacillus)
Robert koch
spreads from 1 host to
another (herpes, typhoid fever, TB, etc)
communicable disease
easility communicable (chickenpox, measles)
contagious disease
not spread from one host to another (e.g. tetanus)
Non communicable disease
occasional and irregular occurrence
(typhoid fever)
sporadic
constantly present in a population (common
cold)
endemic
persistent, high levels of occurrence
hyperendemic
increase, often sudden, in the number of
cases of a disease above what is normally expected
(flu)
Epidemic
an epidemic that has spread over several
countries or continents
pandemic
22 cases of legionellosis occurred within 3 weeks among
residents of a particular neighborhood (usually 0-1 per year)
endemic
Average annual incidence is 364 cases of pulmonary TB per
100,000 population in one area, compared with national
average of 134 cases per 100,000 population.
hyperendemic
Average annual incidence is 364 cases of pulmonary TB per
100,000 population in one area, compared with national
average of 134 cases per 100,000 population.
Pandemic
Single case of histoplasmosis was diagnosed in a
community
epidemic
About 60 cases of gonorrhea are usually reported in this
region per week, slightly less than the national average
sporadic
causative agent remains inactive for a
time but then becomes active to produce symptoms of
the disease (shingles)
Latent disease
develops rapidly but lasts only a short time (flu)
acute disease
intermediate between acute and chrnic
subacute disease
develops more slowly, may be less
severe, but likely to continue or recur for long periods
(infectious mononucleosis, tuberculosis, and hepatitis B)
chronic disease
the invading microorganisms are
limited to a relatively small body area (furuncle,
abscess)
local infection
agents of local infection enter a
blood/lymphatic vessel and spread to other body
parts, where they are confined to specific areas
Focal infection
microorganisms or their
products are spread throughout the body by the
blood/lymph (measles)
systemic infection
systemic infection
from the multiplication of pathogens or spread of toxins in
the blood
Septicemia (“blood poisoning”)
toxic inflammatory reaction to septicemia that
can lead to tissue damage and death
sepsis
disease as a result of the pathogen’s
presence or activity within the normal, healthy host, and
their intrinsic virulence
Primary infection
disease caused by
an opportunistic pathogen in a host with depressed
resistance (immunodeficiency) or if they have unusual
access to the inside of the body
Secondary/opportunistic infection
no noticeable illness (e.g. in carriers)
Subclinical infection