4.6 Antianginal Drugs Flashcards
What is angina pectoris a symptom of?
coronary heart disease
Angina pectoris presents as a sudden, sevre, pressing chest pain resulting from…
myocardial ischemia
With Angina Pectoris the imbalance in oxygen demand may be due to what 3 things?
- Exercise
- A spasm of a vascular muscle
- Obstruction of blood vessels (atherosclerosis)
What type of angina is characterized by chest pain precipitated by some activity, minimal or non-existent symptoms at rest?
Stable Angina
What type of angina is characterized by, chest pain that occurs at rest, and with an increase in the severity, frequency, and duration in patients with previously stable angina?
Unstable angina (acute coronary syndrome)
What type of angina is characterized by chest pain caused by a spasm of a coronary artery?
Variant angina (vasospastic angina)
What are the organic nitrates used to treat angina? (3)
- Nitroglycerin
- Amyl nitrite
- Isosorbide dinitrate
What are the calcium channel blockers used to treat angina? (3)
- Dihydropyridines
- Verapamil
- Diltiazem
What are the beta-blocking drugs used to treat angina?
- Propranolol
- Atenolol
- Metoprolol
What are the newer drugs used to treat angina? (2)
- Ranolazine
- Trimetazidine
What organic nitrate is used as a 1st line for acute angina pectoris attacks?
Nitroglycerine
What can nitroglycerine be comined with to increase its efficacy?
beta-blockers
What organic nitrate is useful in treating cyanide poisoning?
Amyl nitrite
- Nitrite converts hemoglobin to methemoglobin which has a high affinity for cyanide
- Sodium nitrite is an antidote for cyanide
How is amyl nitrite administered?
inhalation
Which organic nitrate is long-acting, and why?
Isosorbide dinitrate
- Through its metabolite mononitrate