4.3 Drugs Acting on the GI Tract Flashcards
1
Q
What is the primary complication of Peptic Ulcer Disease?
A
Hemorrhage
2
Q
What is the drug class of choice for PUD and GERD?
A
PPIs
3
Q
What is the MOA of PPIs?
A
Irreversible inhibit the proton pump in the parietal cell
4
Q
What are PPIs longer lasting and more potent than?
A
Histamine H2-receptor antagonists
5
Q
What are the adverse effects associated with long term PPI use mostly associated with?
A
Alteration of normal gastric pH
- Normal = 1.4
- With PPI use = 5-8
6
Q
What is the side effect when omeprazole (PPI) is used long term for Zollinger Ellison Sx?
A
Gastroduodenal Tumors
7
Q
A
