3.6 Drugs acting on the Respiratory System Flashcards

1
Q

What has a key role in Asthma Pathogenesis?

A

Type 2 Helper T Lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What has a key role in COPD Pathogenesis?

A

Neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What increases bronchodilation via the Sympathetic ANS?

A

B2-adrenergic agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What drecreases bronchoconstriction via the Parasympathetic ANS?

A

Anticholinergics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What inhibits the conversion of cAMP to AMP?

A

Phosphodiesterase Inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are modified catecholamines?

A

B2-adrenergic agonsits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is used to explain the sustained mechanism of action of long-acting B2-adrenergic agonists?

A

Diffusion Microkinetic Theory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What drives the adverse effects resulting from B2-adrenergic receptor desensitization and down-regulation?

A

S-enantiomer of long-acting B2-adrenergic agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where do anticholinergics act on?

A

M3 smooth muscle receptors in the lung

Atropine based

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the functions of Corticosteroids (4)?

A
  • DEC inflammatory cytokine production
  • DEC vascular leakiness
  • DEC mucus secretion
  • INC B2-adrenergic receptor expression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the key difference between the mechanism of action between leukotriene inhibitors versus leukotriene antagonists?

A

Inhibitors, block LTB4 production which reduces neutrophil and eosinophil chemotaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are not effective for Acute Asthmatic Attacks, but are very effective when used Prophylactically?

A

Chromones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is Omalizumab especially effective in treating?

A
  • It is a monoclonal antibody
  • Asthma pts with allergies via blocking free IgE
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which pts experience increased air-flow resistance?

A

Asthma pts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which pts experience low lung recoil?

A

COPD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is it recommended that all asthma pts carry for intermittent asthma attacks?

A

A short acting B2-adrenergic agonist medication

17
Q

A clinical office medical emergency kit should include access to …

A

Oxygen

Epinephrine

18
Q

In general, what combined therapy do COPD pts benefit from?

A

Anticholinergic +

B2-adrenergic agonist therapy

19
Q

What is very effective at increasing mucus clearance?

A

Guaifenesin

20
Q

What is the caviot to using Guaifenesin to increase mucus clearance?

A

Requires pts to maintain sufficient water intake in order to maximize therapeutic effects

21
Q

What are modified catecholamines?

A

B2-adrenergic agonists