41 Disorders of Lipid Metabolism

Question 1

Distinguishing lipoprotein of chylomicrons

Answer 1

apoB48

Question 2

The only form of apolipoprotein B produced by intestinal cells

Answer 2

apoB48

Question 3

Distinguishing apolipoprotein of VLDL particles

Answer 3

apoB100

Question 4

Most abundant apolipoprotein in HDL

Answer 4

apoAI

Question 5

Apolipoprotein that is a potential satiety factor

Answer 5

apoAIV

Question 6

Homozygous mutations for this apolipoprotein increases risk for hyperchylomicronemia and pancreatitis

Answer 6

apoAV

Question 7

Intrathecal administration of this drug may confer clinical benefit in Niemann-Pick type C

Answer 7

Cyclodextrin

Question 8

Only form of apolipoprotein B produced by intestinal cells

Answer 8

apoB48

Question 9

Major carrier of cholesterol in most humans

Answer 9

LDL

Question 10

Treatment for cerebrotendinous xanthomatosis

Answer 10

Chenodeoxycholic acid

Question 11

Characteristic renal biopsy finding in LCAT deficiency

Answer 11

Foam cells

Question 12

Statins (2) that have minimal renal clearance

Answer 12

Atorvastatin
Fluvastatin

Question 13

Half life of pitavastatin

Answer 13

12 hours

Question 14

Half life of atorvastatin

Answer 14

14 hours

Question 15

Half life of rosuvastatin

Answer 15

21 hours

Question 16

Statins (2) that interact with cyclosporine

Answer 16

Pravastatin
Pitavastatin

Question 17

Statin that increases digoxin levels

Answer 17

Atorvastatin

Question 18

Most common side effect of niacin

Answer 18

Cutaneous flushing

Question 19

Statin approved for children 8 years and older

Answer 19

Pravastatin

Question 20

ApoB antisense oligonucleotide approved for treatment of homozygous FH

Answer 20

Mipomersen

Question 21

MTP inhibitor approved for treatment of homozygous FH

Answer 21

Lomitapide

Question 22

Most efficacious therapy to lower the ratio of total cholesterol to HDL

Answer 22

Statins

Question 23

Appearance of this phospholipid on the cell surface initiates blood clotting and marks apoptotic cells for phagocytosis

Answer 23

Phosphatidylserine

Question 24

Enzyme that facilitates hydrolysis of diglycerides

Answer 24

Hormone-sensitive lipase

Question 25

Phosphorylation of perilipin 1 is required for this step in hormone-induced lipolysis

Answer 25

Monoglyceride lipase

Question 26

Coenzyme required for activity of LPL

Answer 26

ApoC-II

Question 27

Coactivator protein required for activity of adipose triglyceride lipase

Answer 27

CGI58

Question 28

Rate limiting enzyme for bile acid synthesis

Answer 28

7 alpha hydroxylase

Question 29

A founder mutation makes LPL deficiency especially common among:

Answer 29

French Canadians

Question 30

Most common causes of autoimmune chylomicronemia

Answer 30

Antibodies to GPIHBP1

Question 31

Hypertriglyceridemia in nephrotic syndrome has been linked to increases circulating levels of this LPL inbibitor

Answer 31

Angiopoietin-like protein 4