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PSBEDM Review > 41 Disorders of Lipid Metabolism > Flashcards

41 Disorders of Lipid Metabolism Flashcards

1
Q

Distinguishing lipoprotein of chylomicrons

A

apoB48

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2
Q

The only form of apolipoprotein B produced by intestinal cells

A

apoB48

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3
Q

Distinguishing apolipoprotein of VLDL particles

A

apoB100

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4
Q

Most abundant apolipoprotein in HDL

A

apoAI

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5
Q

Apolipoprotein that is a potential satiety factor

A

apoAIV

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6
Q

Homozygous mutations for this apolipoprotein increases risk for hyperchylomicronemia and pancreatitis

A

apoAV

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7
Q

Intrathecal administration of this drug may confer clinical benefit in Niemann-Pick type C

A

Cyclodextrin

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8
Q

Only form of apolipoprotein B produced by intestinal cells

A

apoB48

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9
Q

Major carrier of cholesterol in most humans

A

LDL

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10
Q

Treatment for cerebrotendinous xanthomatosis

A

Chenodeoxycholic acid

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11
Q

Characteristic renal biopsy finding in LCAT deficiency

A

Foam cells

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12
Q

Statins (2) that have minimal renal clearance

A

Atorvastatin
Fluvastatin

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13
Q

Half life of pitavastatin

A

12 hours

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14
Q

Half life of atorvastatin

A

14 hours

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15
Q

Half life of rosuvastatin

A

21 hours

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16
Q

Statins (2) that interact with cyclosporine

A

Pravastatin
Pitavastatin

17
Q

Statin that increases digoxin levels

A

Atorvastatin

18
Q

Most common side effect of niacin

A

Cutaneous flushing

19
Q

Statin approved for children 8 years and older

A

Pravastatin

20
Q

ApoB antisense oligonucleotide approved for treatment of homozygous FH

A

Mipomersen

21
Q

MTP inhibitor approved for treatment of homozygous FH

A

Lomitapide

22
Q

Most efficacious therapy to lower the ratio of total cholesterol to HDL

A

Statins

23
Q

Appearance of this phospholipid on the cell surface initiates blood clotting and marks apoptotic cells for phagocytosis

A

Phosphatidylserine

24
Q

Enzyme that facilitates hydrolysis of diglycerides

A

Hormone-sensitive lipase

25
Q

Phosphorylation of perilipin 1 is required for this step in hormone-induced lipolysis

A

Monoglyceride lipase

26
Q

Coenzyme required for activity of LPL

A

ApoC-II

27
Q

Coactivator protein required for activity of adipose triglyceride lipase

A

CGI58

28
Q

Rate limiting enzyme for bile acid synthesis

A

7 alpha hydroxylase

29
Q

A founder mutation makes LPL deficiency especially common among:

A

French Canadians

30
Q

Most common causes of autoimmune chylomicronemia

A

Antibodies to GPIHBP1

31
Q

Hypertriglyceridemia in nephrotic syndrome has been linked to increases circulating levels of this LPL inbibitor

A

Angiopoietin-like protein 4

PSBEDM Review (20 decks)

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