17 Physiology and Pathology of the Female Reproductive Axis

Question 1

Screening test used to rule out nonclassic CAH in women with chronic anovulation and androgen excess

Answer 1

8 AM serum 17-hydroxyprogesterone

Question 2

8 AM serum 17-hydroxyprogesterone level that effectively rules out nonclassic CAH

Answer 2

<2 ng/mL (<200 ng/dL)

Question 3

Basal 8 AM serum 17-hydroxyprogesterone level that confirms nonclassic CAH

Answer 3

> 10 ng/mL (>1000 ng/dL)

Question 4

Further testing used to confirm nonclassic CAH in women with basal 17-OHP between 2-10 ng/mL

Answer 4

ACTH stimulation test

Question 5

8 AM serum 17-hydroxyprogesterone level that confirms nonclassic CAH after ACTH stimulation

Answer 5

> 10 ng/mL (>1000 ng/dL)

Question 6

Most sensitive indication of perimenopause

Answer 6

Progressively increasing occurrence of menstrual irregularities

Question 7

Median age at onset of perimenopause

Answer 7

47.5 years

Question 8

FSH levels in perimenopause

Answer 8

Elevated

Question 9

LH levels in perimenopause

Answer 9

Normal

Question 10

Inhibin levels in perimenopause

Answer 10

Decreased

Question 11

Estradiol levels in perimenopause

Answer 11

Slightly elevated