22 Endocrine Changes in Pregnancy Flashcards
Anterior pituitary gland size increases by an average of __% during pregnancy.
36%
Enlargement of anterior pituitary gland during pregnancy is primarily caused by increase in size and number of these cells
Lactotroph
Lactotroph size and number increases by how much during pregnancy
10-fold
Increased / decreased / unchanged during pregnancy:
Height of pituitary gland
Increased
Increased / decreased / unchanged during pregnancy:
Convexity of pituitary gland
Increased
Increased / decreased / unchanged during pregnancy:
Number of somatotroph
Decreased
Increased / decreased / unchanged during pregnancy:
Number of gonadotroph
Decreased
Increased / decreased / unchanged during pregnancy:
Number of corticotroph
Unchanged
Increased / decreased / unchanged during pregnancy:
Number of thyrotroph
Unchanged
Increased / decreased / unchanged during pregnancy:
Size of posterior pituitary
Decreased
Mean serum prolactin concentration at term
207 ng/mL (range 35-600)
Mean prolactin concentration in nonpregnant premenopausal women
10 ng/mL
Prolactin in amniotic fluid appears to be primarily from
Decidua
Amniotic fluid prolactin levels are how many times higher than in maternal circulation in early pregnancy
10-100x
Serum prolactin levels return to baseline approximately how long after delivery in the absence of breastfeeding
7 days
With suckling, prolactin levels rise within how many minutes
30 minutes
Most common pituitary tumor diagnosed during pregnancy
Prolactinoma
Dopamine agonist used in treating prolactinoma in pregnancy
Bromocriptine
Indications for transsphenoidal resection of prolactinoma during pregnancy (2)
Rapid tumor growth
Persistence of symptoms despite bromocriptine treatment
Increased / decreased / unchanged during pregnancy:
Growth hormone levels in maternal serum
Unchanged
Apart from estrogens, this hormone secreted by the corpus luteum stimulate GH secretion during early pregnancy
Relaxin
Pituitary GH secretion decrease after week __ of pregnancy
Week 25
Pituitary GH is known as GH1 or:
hGH-N
These cells secrete hGH-V beginning in the 4th month of gestation
Placental syncytiotrophoblasts
Placental syncytiotrophoblasts secrete hGH-V beginning this month of gestation
4th month of gestation
Increased / decreased / unchanged :
GH response to insulin hypoglycemia or arginine infusion in the 1st half of gestation
Increased
Increased / decreased / unchanged:
GH response to insulin hypoglycemia or arginine infusion in the 2nd half of gestation
Decreased