29 Hormones and Disorders of Mineral Metabolism

Question 1

Indications to aggressively treat hypercalcemia (2)

Answer 1

Symptomatic
Serum calcium >14 mg/dL

Question 2

Usual dose and frequency of rehydration in the treatment of severe hypercalcemia

Answer 2

2-4 L/day of 0.9% NaCl qd x1-5 days

Question 3

Usual dose and frequency of furosemide in the treatment of severe hypercalcemia

Answer 3

20-40 mg IV q12-24 h after rehydration

Question 4

Usual dose of pamidronate in the treatment of severe hypercalcemia

Answer 4

60-90 mg IV over 2-4 h

Question 5

Usual dose of zoledronic acid in the treatment of severe hypercalcemia

Answer 5

4 mg IV over 15-30 min

Question 6

Usual dose and frequency of denosumab in the treatment of severe hypercalcemia

Answer 6

60 mg SC weekly

Question 7

Usual dose and frequency of calcitonin in the treatment of severe hypercalcemia

Answer 7

4-8 IU/kg SC q12-24 h

Question 8

Usual dose and frequency of gallium nitrate in the treatment of severe hypercalcemia

Answer 8

200 mg/m2 IV over 24 h qd x5 days

Question 9

Usual dose and frequency of hydrocortisone in the treatment of severe hypercalcemia

Answer 9

200-300 mg IV qd x3-5 days

Question 10

Usual dose and frequency of prednisone in the treatment of severe hypercalcemia

Answer 10

40-60 mg PO qd x3-5 days

Question 11

Syndrome characterized by hypoparathyroidism, extreme short stature, mental retardation and dysmorphism caused by mutations in the chaperone protein TBCE

Answer 11

Kenny-Caffey syndrome type 1

Question 12

Autosomal dominant syndrome characterized by short stature, hypoparathyroidism, and osteocraniostenosis caused by mutations in FAM111A

Answer 12

Kenny-Caffey syndrome type 2