4.1 Communicable diseases, disease prevention and the immune system Flashcards
bacteria facts
smaller than eukaryotic cells
reproduce rapidly (20 minutes in optimal conditions)
damage cells through release of toxins
e.g. tuberculosis, meningitis, ring rot (potatoes, tomatoes)
fungi facts
often live in skin
hyphae form mycelium
reproductive hyphae grow into skin and releases pores (redness to skin)
live in vascular tissue in plants to gain nutrients
hyphae release extra cellular digestive enzymes to break down cellulose (decays plant)
e.g. black sigatoka (plants), ringworm (cattle), athlete’s foot
protoctista facts
enter host cell and feed on contents of cell
malaria parasite Plasmodium has immature forms that feed on haemoglobin
e.g. malaria, potato/tomato later blight
viruses facts
invades cell and rakes over genetic machinery and other organelles
causes cells to manufacture more copies of virus
host cell eventually bursts, releasing new viruses to invade new host cells
e.g. HIV, influenza (animals), tobacco mosaic virus (plants)
direct transmission definition
passing a pathogen from host to new host with no intermediary
indirect transmission definition
passing a pathogen from host to new host, via a vector
transmission definition
passing a pathogen from an infected to an uninflected individual
vector definition
organism that carries a pathogen from one host to another
means of transmission
direct physical contact (touching infected people or contaminated surfaces)
faecal-oral transmission (intaking contaminated food or water)
droplet infection (pathogen carried in tiny water droplets in air)
spores (resistant stage of pathogen carried in air or reside on surfaces or soil)
social factors of transmission
overcrowding
poor ventilation
poor health (person who has HIV/AIDS more likely to contract other diseases)
poor diet
homelessness
living with people who migrated from areas where a disease is more common
factors affecting direct physical contact (transmission)
hygiene (wash hands regularly) keeping surfaces clean clean and disinfect cuts and abrasions sterilise surgical instruments use condoms during intercourse
factors affecting faecal-oral transmission
treatment of drinking water
thoroughly wash food (with treated water)
prepare and cook food carefully
factors affecting droplet infection (transmission)
catch it (cover mouth when coughing or sneezing) bin it - kill it (use and dispose tissue)
factors affecting spore transmission
use mask
wash hands after being in contact with soil
indirect transmission of malaria method
gametes of plasmodium in person with malaria
female Anopheles mosquito sucks blood
Plasmodium develops and migrates to mosquito’s salivary glands
uninfected person is bitten
Plasmodium migrates to liver then blood
cycle starts again
direct transmission of plant pathogens
pathogens in soil enter roots of plant (especially if damaged)
fungi produce spores may be carried by wind
may infect vascular tissue
distributed back to soil when leaves shed
may enter fruit and distributed with seeds (so offspring also afflicted)
indirect transmission of plant pathogens
pathogen attaches to insects (vector) when they attack infected plant
they attack uninfected plants and transmit disease
how climate affects disease
grow and reproduce quicker in warm, moist conditions
more common with greater variety in warmer climates
pathogens damaged or killed in cold (winter) weather and stunts rate of reproduction
passive defence definition
defence present before infection and prevents entry and spread of pathogen in organism
physical defences in plants
cellulose cell wall (physical barrier)
lignin thickening of cell walls (waterproof and almost completely indigestible)
waxy cuticle (prevents water that may contain pathogens collecting on cell surface)
bark (physical barrier)
stomatal closure (blocks potential point of entry for pathogen)
callose (large polysaccharide deposited in sieve tube to prevent spread of pathogen around plant)
tylose formation (balloon-like swelling that plugs xylem vessels when full to block spread of pathogens through xylem)
chemical defences in plants
plant tissue contain variety of chemicals with with anti-pathogenic properties
some may be present before infection (terpene in tyloses, tannins in bark)
most are in active defence as chemical production requires a lot of energy
active defence definition
initiated when pathogen is detected inside the organism
active defences in plants
cell walls thicken with more cellulose
deposition
callose deposited between plant cell wall and cell membrane (impedes cellular penetration)
also strengthens cell walls and blocks plasmodesmata
oxidative bursts (highly reactive oxygen molecules, damages cells of invading organisms)
increase production of chemicals
necrosis - deliberate death of infected cells to stop spread
primary defence definition
prevents pathogens entering the body / bloodstream
inflammation definition
swelling and redness of tissue caused by infection
blood clot formation
blood vessel is damaged
platelets bind to exposed collagen to form temporary platelet plug
platelets release clotting factor (activates enzyme cascade)
enzyme cascade causes fibrinogen to form insoluble fibres (attaches to plug)
RBCs trapped (forms clot, dries to form scab)
scab pulls skin together
collagen deposited under skin
stem cells in epidermis divide and differentiate to from new skin cells at edge of cut
new blood vessels form
repair complete when edges of cut drawn together
mucous membrane definition
specialised epithelial tissue covered by mucus
expulsive reflexes
coughing, sneezing, vomiting
irritation caused by presence of microorganisms or their toxins
causes sudden expulsion of air
carries microorganisms causing irritation
inflammation method
mast cells detect microbes and release histamines
causes vasodilation in arterioles (makes capillaries more permeable so WBCs can leave into tissue fluid)
more tissue fluid formed (more plasma leaves)
causes oedema (swelling)
tissue fluid can drain into lymph vessels (pathogens more likely to come into contact with lymphocytes, causing specific immune response)
primary defences in humans examples
skin (physical barrier) blood clotting and skin repair mucous membranes coughing and sneezing (expulsion reflexes) inflammation enzymes in tear fluid (lysozyme) mucous plug in cervix maintaining acidic conditions in vagina
secondary defence definition
combats pathogens that have already entered body/bloodstream
first line of secondary defence
phagocytes (specialised cells in blood and tissue fluid that engulf and digest pathogens)