4. Pancreas and spleen embryology

Question 1

Pancreas derived from

Answer 1

foregut

Question 2

pancreases embryology - is divided into ( and function)

Answer 2

Ventral pancreatic buds —> contribute to uncinate process and main pancreatic duct.
The dorsal pancreatic bud alone –> becomes the body, tail, isthmus, and accessory pancreatic duct.

Both the ventral and dorsal buds contribute to pancreatic head.

Question 3

Annular pancreas ( mechanism and presentation)

Answer 3

ventral pancreatic bud abnormally encircles 2nd part of duodenum; forms a
ring of pancreatic tissue that may cause duodenal narrowing and nonbilious vomiting.

Question 4

Pancreas divisum mechanism

Answer 4

ventral and dorsal parts fail to fuse at 8 week

Question 5

Pancreas divisum - mechanism and symptoms

Answer 5

ventral and dorsal parts fail to fuse at 8 week –> mostly assymptomatic but may cause chronic abdominal pain and / or pancreatitis

Question 6

Splee arises …

Answer 6

in mesentery of stomach ( hence is mesodermal) but has foregut supply celiac trunk –> spleen artery

Question 7

mesntery is a

Answer 7

fold of membranous tissue that arises from posterio wall of the peritoneal cavity and attaches to the interstinal tract

Question 8

• Is the pancreas derived from the foregut, the midgut, or the hindgut?

Answer 8

The foregut

Question 9

• A patient is diagnosed with pancreas divisum, and she asks how this developed. What do you tell her?

Answer 9

Failure of the ventral and dorsal pancreatic buds to fuse during embryologic development

Question 10

• From which dermal layer does the spleen arise: endoderm, mesoderm, or ectoderm?

Answer 10

Mesoderm

Question 11

• The spleen receives blood from the ____ (foregut/midgut/hindgut) vasculature.

Answer 11

Foregut (specifically, the celiac artery) even though the spleen has a mesodermal origin

Question 12

• A patient has a malformed accessory pancreatic duct. What pancreatic bud did not form correctly?

Answer 12

Dorsal pancreatic bud

Question 13

• Ventral pancreatic buds contribute to the formation of these three pancreatic structures.

Answer 13

Pancreatic head, main pancreatic duct, and uncinate process

Question 14

• A child has malformed mesentery of the stomach. What mesodermal organ that is supplied by the celiac artery are you concerned about?

Answer 14

Spleen