4. Multicystic dysplastic kidney

Question 1

mechanism and defition

Answer 1

Ureteric bud fails to induce differentiation of metanphric mesenchyme –> non functional kidney consisting of cysts and connectice tissue

Question 2

definition

Answer 2

nondunctional kidney consisting of cysts and connective tissue

Question 3

diagnosis

Answer 3

often perinatally via ultrasound

Question 4

• During development, an abnormal interaction between an embryo’s ureteric bud and the metanephric mesoderm occurs, Is the kidney functional?

Answer 4

No—this interaction results in a multicystic dysplastic kidney, a nonfunctional kidney consisting of connective tissue and cysts)

Question 5

• Is multicystic dysplastic kidney usually unilateral or bilateral? What are the symptoms and how is the condition diagnosed?

Answer 5

Unilateral; generally asymptomatic, with hypertrophy (compensation) by the other kidney; diagnosed prenatally with ultrasound