14. Changes in glomerular dynamics

Question 1

effect oof NSAIS on renal function

Answer 1

NSAIDS inhibit prostaglandins ( that preferentially dilated afferent arteriole and increase RPF and GFR , no the FF)
–> constriction of afferent arteriole –> RPF and GFR, not FF—> constriction of afferent arteriole –> decrease of RPF and GFR, not the FF -> IN LOW RENAL BLOOD STATES –> ACUTE RENAL FAILURE

Question 2

effect of ACE inhibitors on renal function

Answer 2

ACE inhibitors decrease angiotensin 2 ( that preferentially constricts efferent arteriole and decrease RPF, increase GFR and increase FF) –> dilation of efferent arteriole –> increase RPF, decreased GFR, so decrease FF )

Question 3

prostaglandins vss angiotensin 2 on renal function

Answer 3

prostaglandins –> preferentally dialted affent arteriole and increase RPF and GFR, not he FF
- angiotensin 2 –> preferentially constricts effernt arteriole and decrease RPF, increase GFR and increase FF

Question 4

Affrent arteriole constriction -

GFR, RPF, FF?

Answer 4

GFR,: decreased
RPF: decreased
FF:-

Question 5

Efferent artetiole constriction

GFR, RPF, FF?

Answer 5

GFR,: increased
RPF: decreased
FF: increased

Question 6

increased plasma protein concentration

GFR, RPF, FF?

Answer 6

GFR,:decreased
RPF:-
FF:decreased

Question 7

decreased plasma protein concentration

GFR, RPF, FF?

Answer 7

GFR,:increased
RPF:-
FF:increased

Question 8

constriction of ureter

GFR, RPF, FF?

Answer 8

GFR,:decreased
RPF:-
FF:decreased

Question 9

dehydration

GFR, RPF, FF?

Answer 9

GFR,:decreased
RPF: decreased
FF: iNCREASED

Question 10

filtration fruction on dehydration

Answer 10

increased

Question 11

• Describe the effects of afferent arteriole constriction on renal plasma flow, glomerular filtration rate, and filtration fraction.

Answer 11

Renal plasma flow decreases; glomerular filtration rate decreases; filtration fraction does not change

Question 12

• Describe the effects of efferent arteriole constriction on renal plasma flow, glomerular filtration rate, and filtration fraction.

Answer 12

Renal plasma flow decreases; glomerular filtration rate increases; filtration fraction increases

Question 13

• Describe the effects of elevated plasma protein concentration on renal plasma flow, glomerular filtration rate, and filtration fraction.

Answer 13

Renal plasma flow does not change; glomerular filtration rate decreases; filtration fraction decreases

Question 14

• Describe the effects of reduced plasma protein concentration on renal plasma flow, glomerular filtration rate, and filtration fraction.

Answer 14

Renal plasma flow does not change; glomerular filtration rate increases; filtration fraction increases

Question 15

• Describe the effects of ureter constriction on renal plasma flow, glomerular filtration rate, and filtration fraction.

Answer 15

Renal plasma flow does not change; glomerular filtration rate decreases; filtration fraction decreases