4- inflammatory & malignant pancreaticobiliary disease Flashcards

1
Q

what is HPB surgery?

A

hepatobiliary surgery

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2
Q

are all biliary trees the same?

A

no - lots of variation

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3
Q

what is ERCP?

A

therapeutic procedure - endoscopy where go through oesophagus,stomach, duodenum , open ampulla and squirt dye to see anatomy of biliary tree

→use to visualise biliary and see if any stones, cancer, stricture

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4
Q

what is structure of pancreas?

A

4 segments = head, neck, body & tail

head has uncinate process which is like tongue going behind 2 vessels (superior mesenteric vessels)
= it like loops around them

the 3rd part of duodenum is also behind superior mesenteric vessels

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5
Q

what happens if need pancreas removed?

A

means you’re a special type of diabetic (3C) - don’t produce insulin or glucagon →at risk of hypoglycemic episodes

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6
Q

what is inflammatory HPB diseases?

A

= inflammatory or benign can be severe & life threatening
- commonly due to gall stones

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7
Q

is surgery for removal of gallstones common?

A

no = risks of operation of removing gallstones is much higher than benefits so not common

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8
Q

where are gallstones formed?

A

mostly formed in gallbladder but any type of bile stasis can cause gallstones so can form anywhere in biliary tree

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9
Q

what are the 4 types of gallstones?

A

cholesterol, pigmented, calcium & mixed

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10
Q

what are risk factors for gallstones?

A

female sex, obesity, contraceptives, age, fatty diet, rapid weight loss (gastric bypass), haemolytic anaemia

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11
Q

what are complications of gallstones?

A
  • biliary pain/biliary colic
  • acute cholecystitis
  • ascending cholangitis
  • pancreatitis
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12
Q

what is biliary pain/biliary colic common presentation?

A

everytime eat gallbladder contracts and causes irritation and pain = people see usually after eating, feels like wind but goes away, may have nausea or acid reflux

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13
Q

what are investigations for biliary pain?

A
  • U&E, FBC, LFTs (may be normal)
  • ultrasound (if see stones here then make plan)
  • MRCP (MRI test that will image biliary tree)
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14
Q

what is treatment of biliary pain?

A

change in diet & analgesia then if still symptoms = laparoscopic cholecystectomy

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15
Q

what is common presentation of acute cholecystitis?

A

if gallstone blocks then infection occurs and inflammation →fever, pain, nausea, vomiting. Murphy’s sign = abdominal exam of RUQ pain (stop breathing in due to pain)

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16
Q

what are investigations for acute cholecystitis?

A

high WWC/CRP, possible raised LFTs

17
Q

what is treatment for acute cholecystitis?

A

antibiotics, analgesia (fluids) , laparoscopic cholecystectomy

18
Q

what is ascending cholangitis?

A

stones go down main bile duct, can then get stuck there and this can cause jaundice & infection within biliary tree (much more severe than just infection for gallbladder as affects loads of areas) - can lead to abscesses = long hospitalisation to drain pus

19
Q

what are symptoms of ascending cholangitis?

A
  • pain, jaundice, pale stools & dark urine
  • charcot triad (fever, RUQ, jaundice)
  • sepsis (fever, tachycardia, low BP), jaundice
20
Q

what are investigations for ascending cholangitis?

A
  • bloods (U&Es, LFTs, amylase, CRP)
  • ultrasound
21
Q

what is treatment for ascending cholangitis?

A
  • IV antibiotics
  • ERCP
22
Q

what is pancreatitis?

A

stone comes down through bile duct and goes through intrapancreatic bile duct →cause inflammation everywhere in pancreas = very serious (mostly fatal)

23
Q

what are causes of pancreatitis (mnemonic)?

A

I GET SMASHED

I = idiopathic

G = gallstones
E = ethanol
T = trauma

S = steroids
M = mumps/malignancy
A = autoimmune
S = scorpion stings
H = hypercalcaemia/hipertrigliceridemia
E = ERCP
D = drugs (thiazide diuretics, azathioprine etc)

24
Q

what are symptoms of gallstone pancreatitis?

A

main cause stone stuck in bile duct →can be life threatening

  • severe epigastric pain radiating to back, vomiting
25
Q

what are diagnostic biochemical findings if gallstone pancreatitis?

A

raised amylase & often raised LFTs, raised CRP

26
Q

what is treatment of acute pancreatitis?

A
  • supportive measures →aggressive fluid resuscitation, analgesia, nutrition, antibiotics (debatable)
  • removing cause - ERCP
  • preventing future attacks →laparoscopic cholecystectomy
27
Q

what are main malignant HPB diseases?

A
  • hepatocellular carcinoma
  • cholangiocarcinoma
  • gallbladder cancer
  • pancreatic cancer
28
Q

what diagnostic biochemical finding is for hepatocellular carcinoma?

A

increased AFP

29
Q

what is treatment for hepatocellular carcinoma?

A

→surgery, TACE, ablation, chemotherapy

30
Q

what is cholangiocarcinoma?

A
  • cancer of bile ducts
  • 3 types →hilar, intrahepatic, extrahepatic
31
Q

what is prognosis like for gallbladder cancer?

A
  • poor prognosis
  • few cases can have surgery
  • low response rates to chemo
32
Q

what is prognosis like for pancreatic cancer?

A
  • lowest 5 year survival among solid malignancies
  • usually find late because symptoms start late