36 - Pharmacodynamics II

Question 1

do u know

Answer 1

review

Question 2

What is pharmacodynamics generally?

Answer 2

Question 3

How do we describe drug-receptor affinity?

Answer 3

Question 4

How do we determine the relationship between drug concentration and the biologic effect of the drug?

Answer 4

Question 5

How do we assess dose vs effect visually? (log)

Answer 5

Question 6

What are agonists?

Answer 6

Question 7

What are partial agonists? How does that effect fose vs effect?

Answer 7

Question 8

What happens when you combine a full agonist with a partial agonist?

Answer 8

Question 9

What are super agonists?

Answer 9

Question 10

What are antagonists generally?

Answer 10

Question 11

Describe competitive antagonists and their modification of a dose/effect curve

Answer 11

Question 12

Describe non-competitive antagonists and their modification of a dose/effect curve

Answer 12

Question 13

Describe inverse agonists and their modification of a dose/effect curve

Answer 13

essentially an antagonist (but not really since the receptor has intrinsic activity)

Question 14

What are the classifications of drug-receptor interactions involving agonists and antagonists?

Answer 14

Question 15

Give a very quick graphical overview of dose-effect curve modification in presence of agonist/antagonist

Answer 15

Question 16

What is a quantal dose effect curve?

Answer 16

Question 17

What is the therapeutic index?

Answer 17

Question 18

What is the therapeutic window?

Answer 18

Question 19

What is the difference between graded and quantal does effect curves?

Answer 19

Dose-response relationships may be graded or quantal.

Graded dose-response relationships:
    a Graded dose-response relationship describes a drug effect which increases in proportion to increasing drug dose.
    A graded response to a drug is seen in an individual, and increases with dose.
    Graded dose-response graphs plot the response to a drug against its concentration
Quantal dose-response relationships:
    a Quantal dose-response relationship describes a drug effect which is binary (either present or absent).
    A quantal response to a drug is observed in a population, and is either present or absent in any single individual.
    Quantal dose-response graphs plot the rate of an outcome occurrence in a population against the drug dose.

aka:

"There is a graded dose-response relationship in an individual and a quantal dose-response relationship in the population. Graded doses of a drug given to an individual usually result in a greater magnitude of response as the dose increases. In a quantal dose-response relationship, the percentage of the population affected increases as the dose is increased; the relationship is quantal in that the effect is judged to be either present or absent in a given individual."