28 - ECM Flashcards by Jason Yin

Q

What is the ECM broadly? What important macromolecules does it contain? What does it do?

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Do you know these?

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review

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Q

What is the structure and function of collagen? Where is it found?

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Q

How is collagen synthesized?

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Q

What residues make up collagen? Why is this important?

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Q

How is the triple helix stabilized and strengthened (overview)?

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Q

What is fibrillar collagen?

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Q

What are the types of collagen?

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Q

What are some structural variations in collagen?

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Q

What are elastic fibers (overview)? Where are they found? What are their general structure, composition, and function?

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Q

What is a disease associated with improper elastic fiber production?

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Q

What is fibronectin? What is it used for? What is its general structure and function?

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Q

What are fibronection isoforms? How are they made? What are the consequences of this?

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Q

What does mutations in fibronection formation cause?

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Q

What are proteoglycans? General structure and function?

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Q

What are glycosaminoglycans (GAGs)? General structure and function? Common ones?

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Q

What is the basement membrane generally? What is it composed of/contain? General structure and function?

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Laminins, type 4 collagen, perlecan, nidogen (entactin)

Q

What are laminins?

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Q

What is type 4 collagen?

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Q

What is perlecan? What do mutations in perlecan result in?

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Q

What is nideogen (entactin)? General structure and function?

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Q

What is the function role of the basal lamina (which contains the basement membrane)?

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Q

What is Alport’s syndrome? What does it affect? Common symptoms?

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Q

Why is ECM remodeling necessary? How is it performed? What molecules are most relevant?

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Q

What are matrix metalloproteinases (MMPs)? What do they do? How are they classified?

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What is the structure of MMPs? How does that relate to their function?

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Q

What are some relatives of MMPs (molecules with similar function of MMPs)? What are the structural similarities?

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What are TIMPs (tissue INHIBITORS of metalloproteinases)?

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Q

How do MMPs and TIMPs function in development and disease?

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Q

What are the modes of action of MMPs?

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Q

How does epithelial branching morphogenesis depend on the balance of MMPS and TIMPs?

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Q

What is the role of MMPs in dermal wound healing?

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Q

What is the role of MMPs in the replacement of normal tissue with fibrotic tissue?

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