34 - Pharmacokinetics II Flashcards by Jason Yin

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do u know?

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review

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explain drug half-life generally

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how are drug half-life calculations done in the real world (patient specific based on drug level is plasma)?

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Q

Describe the concept of bioabailability

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Q

what 2 main factors determine drug bioavailability for orally administered drugs?

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Q

what is drug metabolism generally?

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What are the major sites of drug metabolism?

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What is first pass metabolism?

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Q

explain hepatic clearance

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What are the 2 phase pathways of drug metabolism?

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What are the major drug metabolizing enzymes for the 2 phase pathways of drug metabolism?

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Q

What drug metaboliing enzymes are specific to phase 1 metabolism (redox+hydrolysis->hydrophilic)?

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Q

Describe oxidation reactions in the concept of phase 1 drug metabolism.

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Describe hydrolysis reactions in the concept of phase 1 drug metabolism.

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Describe phase 2 conjugation reactions in drug metabolism. What enzymes are associated with these processes?

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What is microsomal enzyme induction in the scope of drug metabolism? How is it performed?

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How does microsomal enzyme induction affect the kinetics of drug metabolism specifically?

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What is the significance of microsomal enzyme induction?

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What is microsomal enzyme inhibition? How does it affect the specific kinetics of drug metabolism?

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What factors affect individual variability in drug metabolism?

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What are the routes of drug excretion?

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Describe renal drug excretion

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describe biliary drug excretion

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describe enterohepatic recirculation

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What is the time course of drug effects (overview)?

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