34 - Pharmacokinetics II Flashcards
do u know?
review
explain drug half-life generally
how are drug half-life calculations done in the real world (patient specific based on drug level is plasma)?
Describe the concept of bioabailability
what 2 main factors determine drug bioavailability for orally administered drugs?
what is drug metabolism generally?
What are the major sites of drug metabolism?
What is first pass metabolism?
explain hepatic clearance
What are the 2 phase pathways of drug metabolism?
What are the major drug metabolizing enzymes for the 2 phase pathways of drug metabolism?
What drug metaboliing enzymes are specific to phase 1 metabolism (redox+hydrolysis->hydrophilic)?
Describe oxidation reactions in the concept of phase 1 drug metabolism.