33 - Pharmacokinetics 1

Question 1

do u know?

Answer 1

review

Question 2

What are the goals of therapeutics?

Answer 2

Question 3

how is a therapeutic’s dosing regimen determined (general considerations)?

Answer 3

Question 4

What is the “correct” drug dose?

Answer 4

Question 5

How does drug ionization affect transport generally?

Answer 5

Question 6

Explain drug ionization

Answer 6

Question 7

Question 8

How are drugs transported across lipid membranes (4 ways)?

Question 9

explain lipid membrane diffusion

Answer 9

Question 10

explain aqueous diffusion across membranes

Answer 10

Question 11

explain lipid membrane transport proteins

Answer 11

Question 12

Explain atp-binding casette (ABC) proteins

Answer 12

Question 13

explain the concept of volume of distribution (Vd)

Answer 13

Question 14

what is drug plasma protein binding?

Answer 14

Question 15

how do drugs get distributed into fat and other tissues

Answer 15

Question 16

What are well-known barriers to drug distrubution? (think blood)

Answer 16

Question 17

How are drugs cleared from the body (very general overview)?

Answer 17

Question 18

describe first order kinetic clearance of drug from the body

Answer 18

Question 19

describe zeroth order kinetic clearance of drug from the body

Answer 19

Question 20

what is the difference between first order and zeroth order kinetics?

Answer 20

Question 21

What factors influence indicidual variability in drug clearance?

Answer 21