27 - Cell Signaling and Cell Adhesion Flashcards
Where are cell-adhesion molecules important?
What are the types of epithelial cell junctions?
Describe cadherins. What are they used for? Where are they found? Why are they important?
Describe selectin. What are they used for? Where are they found? Why are they important?
What is the immunoglobulin superfamily? What are they important for? Where are they found?
What are integrins? What are they used for? Where are they found? Why are they important?
What diseases are associated with integrin defects?
How are leukocytes recruited in acute imflammation?
What is the epithelial-mesenchymal transition (EMT) and how does it relate to cadherins in tumorigenesis?
What is pemphigus?
What are other diseases associated with cellular adhesion molecules (CAMs)?
How do signal molecules bind to their receptors?
What types of molecules act as signals?
What are second messengers? What are some common examples?
What are common shared steps in signaling pathways?
How is a signaling process terminated? What methods are most common?
What are the 3 major classes of cell-surface receptor proteins?
What is a GPCR? What is the mechanism of how GPCRs work? What are some well-known diseases associated with GPCRs?
What are 3 potential downstream pathways of GPCR?
What are the common families of G-proteins and which pathways are they used in?
What hormons are important in cAMP mediated cell response?
What other molecules can G-proteins signal with?
What are the 5 most common classification of enzyme-coupled (catalytic) receptors?
How is a a signal transduced in RTKs (RAS pathway)?
How is a signal transduced in RTKs [insulin receptor-protein kinase B (AKT) pathway]?
What are some major ligans of RTKs and what is the response generated from binding of that ligand?
How is a signal transduced by Serine/threonine kinase receptors (TGF-β/Smad pathway)?
How is a signal transduced by tyrosine kinase associated receptors (Jak/Stat pathway)?
Which receptors activate the Jak-Stat signaling pathway?
Is there any overlap in the major signaling pathways we discussed?
What type of receptor is a nuclear receptor? What is the mechanism of a nuclear receptor?
intracellular receptor/transcription factor initiated. Conformational change iinduced by ligand binding for transcription induction.
What are some popular ligands of nuclear receptors?
What are some alternative signaling pathways in gene regulation?
