Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

General Patho > 30. amyloidosis > Flashcards

30. amyloidosis Flashcards

1
Q

whats amyloid

A

abnormal protein, chemically different in different species and diseases, morphologically similiar, deposited extracellularly in tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

does amyloidosis induce an inflammatory reaction

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

two main types of amyloidosis

A

immune mediated and non immune mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

describe morphology of amyloid protein

A

fibrils, composed of protofilaments, fibre network, beta sheets, unique in staining and optical characteristics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

physical properties of amyloid proteins

A

formed by different proteins with abnormal structure, change os structure is consequence of different effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

are amyloids soluble in water

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

are amyloids soluble in acids or bases

A

poorly soluble in acids, soluble in bases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

amyloid HE staining

A

pink, homogenous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

amyoid congo red staining

A

orange

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

amyloid polarised light staining

A

golden shining

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

amyloid pas staining

A

red

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

amyloid toluidine blue staining

A

red

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

amyloid immunohistochemistry staining

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

amyloid macroscopic staining

A

KI and sulphuric acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

colours of amyloid under KI and sulphuric acid staining

A

brown then blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

features of structurally stable amyloid

A

trypsin resistant, needs pretreatment with acids to be digested with trypsin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

features of structurally instable amyloid

A

can be digested with trypsin without pretreatment

18
Q

two types of amyloidosis

A

primary and secondary

19
Q

immune mediated amyloidosis pathogenesis

A

monoclonal B-lymphocyte proliferation - plasma cell activation - immunoglobulins light chains - AL protein

20
Q

immune mediated amyloidosis results in what

A

primary amyloidosis

21
Q

non immune mediated amyloidosis pathogenesis

A

chronic inflammation - macrophage activation - IL1 and 6 production - abnormal protein production in hepatocytes - SAA protein - AA protein

22
Q

non immun mediated amyloidosis results in what

A

secondary amyloidosis

23
Q

whats secondary amyloidosis

A

preceded by tissue necrosis, chronic inflammation or production of endotoxins, in vaccinated animals with bacterin vaccine, in horses for hyperimmune serum production

24
Q

why is secondary amyloidosis called typical

A

occurs on characteristic sites

25
Q

why is secondary amyloidsis called systemic

A

observed in several organs

26
Q

how do we recognise amyloidosis

A

mostly by macroscopic investigation, by histopathology

27
Q

where might we see local amyloidosis macroscopically

A

predilection sites

28
Q

where might we see systemic amyloidosis macroscopically

A

liver, spleen, kidney, adrenal gland, intestines

29
Q

harmful effects of amyloid

A

intercellular deposition, blocks normal transfer of materials, loss of function, regressive changes in tissues - these cause problems not amyloid itself

30
Q

pathology of systemic amyloidosis in the liver

A
  • shape normal, enlarged
  • pale, in birds sometimes green
  • dry cut surface, easy to tear
  • amyloid deposited on basal membrane of sinusoids of walls of blood vessels
31
Q

pathology of systemic amyloidosis in the spleen

A

deposition in vessels of vascular elements of malpighi bodies

32
Q

pathology of systemic amyloidosis in the kidneys

A
  • deposition on basal membrane of glomerular capillaries and tubuli
  • in or on walls of blood vessels of interstitium
33
Q

pathology of systemic amyloidosis in the adrenal gland

A

in the walls of the capillaries of the cortex

34
Q

pathology of systemic amyloidosis in the intestines

A

on basal membrane of capillaries of microvilli or intestinal glands

35
Q

whats atypical amyloidosis

A

we dont know cause or pathomechanism

36
Q

where does local amyloidosis occur in the body

A

predilection sites of the body

37
Q

where does local amyloidosis occur in horses

A

in the skin or the mucosa of the nasal cavity, tumour like swellings

38
Q

where does local amyloidosis occur in dogs and cats

A

in heart muscle or leptomeninx of aging animals

39
Q

whats APUD-amyloidosis

A

the production and decarboxylation of amine precurses

40
Q

result of APUD-amyloidosis

A

these active polypeptides will eb secreted into the cells environment after decarboxylation and amyloid is made from excess protein

41
Q

cells of APUD system

A
  • enterochromaffin cells of stomach and intestinal walls
  • parafollicular C cells of thyroid gland
  • alpha and beta cells of langerhans islets
  • ACTH-producing cells of adenohypophysis

General Patho (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions